Lack of association between the-2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation

P.G. McGlinchey; M.S. Spence; Christopher Patterson; A.R. Allen; G. Murphy; Christine Belton; Pascal McKeown

doi:10.1111/j.1399-0039.2004.00281.x

Lack of association between the-2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation

P.G. McGlinchey, M.S. Spence, Christopher Patterson, A.R. Allen, G. Murphy, Christine Belton, Pascal McKeown

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Using two recently described family-based tests of association, the possible role of the functional -2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population. One thousand and twelve individuals from 386 families with at least one member prematurely affected with M were, genotyped for the MCP-1 -2518G/A polymorphism. Using the combined transmission disequilibriurn test and the pedigree disequilibriurn test, no association between the MCP-1 -2518G/A polymorphism and M was found. g Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with M.

Original language	English
Pages (from-to)	199-203
Number of pages	5
Journal	Tissue Antigens
Volume	64
Issue number	2
DOIs	https://doi.org/10.1111/j.1399-0039.2004.00281.x
Publication status	Published - Aug 2004

ASJC Scopus subject areas

Immunology
Cell Biology

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10.1111/j.1399-0039.2004.00281.x

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title = "Lack of association between the-2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation",

abstract = "Using two recently described family-based tests of association, the possible role of the functional -2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population. One thousand and twelve individuals from 386 families with at least one member prematurely affected with M were, genotyped for the MCP-1 -2518G/A polymorphism. Using the combined transmission disequilibriurn test and the pedigree disequilibriurn test, no association between the MCP-1 -2518G/A polymorphism and M was found. g Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with M.",

author = "P.G. McGlinchey and M.S. Spence and Christopher Patterson and A.R. Allen and G. Murphy and Christine Belton and Pascal McKeown",

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Lack of association between the-2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation. / McGlinchey, P.G.; Spence, M.S.; Patterson, Christopher; Allen, A.R.; Murphy, G.; Belton, Christine ; McKeown, Pascal.

In: Tissue Antigens, Vol. 64, No. 2, 08.2004, p. 199-203.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Lack of association between the-2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation

AU - McGlinchey, P.G.

AU - Spence, M.S.

AU - Patterson, Christopher

AU - Allen, A.R.

AU - Murphy, G.

AU - Belton, Christine

AU - McKeown, Pascal

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AB - Using two recently described family-based tests of association, the possible role of the functional -2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population. One thousand and twelve individuals from 386 families with at least one member prematurely affected with M were, genotyped for the MCP-1 -2518G/A polymorphism. Using the combined transmission disequilibriurn test and the pedigree disequilibriurn test, no association between the MCP-1 -2518G/A polymorphism and M was found. g Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with M.

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DO - 10.1111/j.1399-0039.2004.00281.x

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EP - 203

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JF - Tissue Antigens

SN - 0001-2815

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Lack of association between the-2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation

Abstract

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