TY - JOUR
T1 - Lack of association between the-2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation
AU - McGlinchey, P.G.
AU - Spence, M.S.
AU - Patterson, Christopher
AU - Allen, A.R.
AU - Murphy, G.
AU - Belton, Christine
AU - McKeown, Pascal
PY - 2004/8
Y1 - 2004/8
N2 - Using two recently described family-based tests of association, the possible role of the functional -2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population. One thousand and twelve individuals from 386 families with at least one member prematurely affected with M were, genotyped for the MCP-1 -2518G/A polymorphism. Using the combined transmission disequilibriurn test and the pedigree disequilibriurn test, no association between the MCP-1 -2518G/A polymorphism and M was found. g Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with M.
AB - Using two recently described family-based tests of association, the possible role of the functional -2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population. One thousand and twelve individuals from 386 families with at least one member prematurely affected with M were, genotyped for the MCP-1 -2518G/A polymorphism. Using the combined transmission disequilibriurn test and the pedigree disequilibriurn test, no association between the MCP-1 -2518G/A polymorphism and M was found. g Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with M.
UR - http://www.scopus.com/inward/record.url?scp=3242797289&partnerID=8YFLogxK
U2 - 10.1111/j.1399-0039.2004.00281.x
DO - 10.1111/j.1399-0039.2004.00281.x
M3 - Article
VL - 64
SP - 199
EP - 203
JO - Tissue Antigens
JF - Tissue Antigens
IS - 2
ER -