Lack of association between the-2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation

P.G. McGlinchey, M.S. Spence, Christopher Patterson, A.R. Allen, G. Murphy, Christine Belton, Pascal McKeown

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10 Citations (Scopus)

Abstract

Using two recently described family-based tests of association, the possible role of the functional -2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population. One thousand and twelve individuals from 386 families with at least one member prematurely affected with M were, genotyped for the MCP-1 -2518G/A polymorphism. Using the combined transmission disequilibriurn test and the pedigree disequilibriurn test, no association between the MCP-1 -2518G/A polymorphism and M was found. g Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with M.
Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalTissue Antigens
Volume64
Issue number2
DOIs
Publication statusPublished - Aug 2004

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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