Lack of in vitro and in vivo effects of lipopolysaccharide on porcine circovirus type 2 infection

L.T. Fernandes, E. Mateu, M. Sibila, M. Fort, A. Andaluz, F. McNeilly, Gordon Allan, A. Sanchez, J. Segales, L. Stevenson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome (PMWS). The presence of immunostimulating factors or concurrent infections seems to be crucial for PMWS development. Lipopolysaccharide (LPS) is a potent immunological activator and has recently been suggested to enhance PCV2 replication in vitro. This study was designed to evaluate the effects of different LPS products on PCV2 in vitro replication of pulmonary macrophages (PMs), and on the potential ability to trigger PMWS in cesarean-derived, colostrum-deprived (CDCD) PCV2-inoculated piglets. In vitro studies using two different PCV2 isolates (Stoon-1010 and 1452/3) showed the presence of PCV2 antigen within the cytoplasm to a variable degree; PCV2 Stoon-1010 was barely detectable (
Original languageEnglish
Pages (from-to)541-552
Number of pages12
JournalViral Immunology
Volume20
Issue number4
DOIs
Publication statusPublished - 01 Dec 2007

ASJC Scopus subject areas

  • Immunology
  • Virology

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    Fernandes, L. T., Mateu, E., Sibila, M., Fort, M., Andaluz, A., McNeilly, F., Allan, G., Sanchez, A., Segales, J., & Stevenson, L. (2007). Lack of in vitro and in vivo effects of lipopolysaccharide on porcine circovirus type 2 infection. Viral Immunology, 20(4), 541-552. https://doi.org/10.1089/vim.2007.0065