Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

H. Schunkert; I.R. Konig; S. Kathiresan; M.P. Reilly; T.L. Assimes; H. Holm; M. Preuss; A.F.R. Stewart; M. Barbalic; C. Gieger; D. Absher; Z. Aherrahrou; H. Allayee; D. Altshuler; S.S. Anand; K. Andersen; J.L. Anderson; D. Ardissino; S.G. Ball; A.J. Balmforth; T.A. Barnes; D.M. Becker; L.C. Becker; K. Berger; J.C. Bis; S.M. Boekholdt; E. Boerwinkle; P.S. Braund; M.J. Brown; M.S. Burnett; I. Buysschaert; J.F. Carlquist; L. Chen; S. Cichon; V. Codd; R.W. Davies; G. Dedoussis; A. Dehghan; S. Demissie; J.M. Devaney; P. Diemert; R. Do; A. Doering; S. Eifert; N.E. El Mokhtari; S.G. Ellis; R. Elosua; J.C. Engert; S.E. Epstein; U. De Faire; M. Fischer; A.R. Folsom; J. Freyer; B. Gigante; D. Girelli; S. Gretarsdottir; V. Gudnason; J.R. Gulcher; E. Halperin; N. Hammond; S.L. Hazen; A. Hofman; B.D. Horne; T. Illig; C. Iribarren; G.T. Jones; J.W. Jukema; M.A. Kaiser; L.M. Kaplan; J.J.P. Kastelein; K.T. Khaw; J.W. Knowles; G. Kolovou; A. Kong; R. Laaksonen; D. Lambrechts; K. Leander; G. Lettre; M.Y. Li; W. Lieb; C. Loley; A.J. Lotery; P.M. Mannucci; S. Maouche; N. Martinelli; Pascal McKeown; C. Meisinger; T. Meitinger; O. Melander; P.A. Merlini; V. Mooser; T. Morgan; T.W. Muhleisen; J.B. Muhlestein; T. Munzel; K. Musunuru; J. Nahrstaedt; C.P. Nelson; M.M. Nothen; O. Olivieri; R.S. Patel; Christopher Patterson; A. Peters; F. Peyvandi; L. Qu; A.A. Quyyumi; D.J. Rader; L.S. Rallidis; C. Rice; F.R. Rosendaal; D. Rubin; V. Salomaa; M.L. Sampietro; M.S. Sandhu; E. Schadt; A. Schafer; A. Schillert; S. Schreiber; J. Schrezenmeir; S.M. Schwartz; D.S. Siscovick; M. Sivananthan; S. Sivapalaratnam; A. Smith; T.B. Smith; J.D. Snoep; N. Soranzo; J.A. Spertus; K. Stark; K. Stirrups; M. Stoll; W.H.W. Tang; S. Tennstedt; G. Thorgeirsson; G. Thorleifsson; M. Tomaszewski; A.G. Uitterlinden; A.M. Van Rij; B.F. Voight; N.J. Wareham; G.A. Wells; H.E. Wichmann; P.S. Wild; C. Willenborg; J.C.M. Witteman; B.J. Wright; S. Ye; T. Zeller; A. Ziegler; F. Cambien; A.H. Goodall; L.A. Cupples; T. Quertermous; W. Marz; C. Hengstenberg; S. Blankenberg; W.H. Ouwehand; A.S. Hall; P. Deloukas; J.R. Thompson; K. Stefansson; R. Roberts; U. Thorsteinsdottir; C.J. O'Donnell; Ruth McPherson; J. Erdmann; N.J. Samani

doi:10.1038/ng.784

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

H. Schunkert, I.R. Konig, S. Kathiresan, M.P. Reilly, T.L. Assimes, H. Holm, M. Preuss, A.F.R. Stewart, M. Barbalic, C. Gieger, D. Absher, Z. Aherrahrou, H. Allayee, D. Altshuler, S.S. Anand, K. Andersen, J.L. Anderson, D. Ardissino, S.G. Ball, A.J. BalmforthT.A. Barnes, D.M. Becker, L.C. Becker, K. Berger, J.C. Bis, S.M. Boekholdt, E. Boerwinkle, P.S. Braund, M.J. Brown, M.S. Burnett, I. Buysschaert, J.F. Carlquist, L. Chen, S. Cichon, V. Codd, R.W. Davies, G. Dedoussis, A. Dehghan, S. Demissie, J.M. Devaney, P. Diemert, R. Do, A. Doering, S. Eifert, N.E. El Mokhtari, S.G. Ellis, R. Elosua, J.C. Engert, S.E. Epstein, U. De Faire, M. Fischer, A.R. Folsom, J. Freyer, B. Gigante, D. Girelli, S. Gretarsdottir, V. Gudnason, J.R. Gulcher, E. Halperin, N. Hammond, S.L. Hazen, A. Hofman, B.D. Horne, T. Illig, C. Iribarren, G.T. Jones, J.W. Jukema, M.A. Kaiser, L.M. Kaplan, J.J.P. Kastelein, K.T. Khaw, J.W. Knowles, G. Kolovou, A. Kong, R. Laaksonen, D. Lambrechts, K. Leander, G. Lettre, M.Y. Li, W. Lieb, C. Loley, A.J. Lotery, P.M. Mannucci, S. Maouche, N. Martinelli, Pascal McKeown, C. Meisinger, T. Meitinger, O. Melander, P.A. Merlini, V. Mooser, T. Morgan, T.W. Muhleisen, J.B. Muhlestein, T. Munzel, K. Musunuru, J. Nahrstaedt, C.P. Nelson, M.M. Nothen, O. Olivieri, R.S. Patel, Christopher Patterson, A. Peters, F. Peyvandi, L. Qu, A.A. Quyyumi, D.J. Rader, L.S. Rallidis, C. Rice, F.R. Rosendaal, D. Rubin, V. Salomaa, M.L. Sampietro, M.S. Sandhu, E. Schadt, A. Schafer, A. Schillert, S. Schreiber, J. Schrezenmeir, S.M. Schwartz, D.S. Siscovick, M. Sivananthan, S. Sivapalaratnam, A. Smith, T.B. Smith, J.D. Snoep, N. Soranzo, J.A. Spertus, K. Stark, K. Stirrups, M. Stoll, W.H.W. Tang, S. Tennstedt, G. Thorgeirsson, G. Thorleifsson, M. Tomaszewski, A.G. Uitterlinden, A.M. Van Rij, B.F. Voight, N.J. Wareham, G.A. Wells, H.E. Wichmann, P.S. Wild, C. Willenborg, J.C.M. Witteman, B.J. Wright, S. Ye, T. Zeller, A. Ziegler, F. Cambien, A.H. Goodall, L.A. Cupples, T. Quertermous, W. Marz, C. Hengstenberg, S. Blankenberg, W.H. Ouwehand, A.S. Hall, P. Deloukas, J.R. Thompson, K. Stefansson, R. Roberts, U. Thorsteinsdottir, C.J. O'Donnell, Ruth McPherson, J. Erdmann, N.J. Samani

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Abstract

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

Original language	English
Pages (from-to)	333-U153
Journal	Nature Genetics
Volume	43
Issue number	4
DOIs	https://doi.org/10.1038/ng.784
Publication status	Published - Apr 2011

ASJC Scopus subject areas

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ng.784

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Schunkert, H., Konig, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., Preuss, M., Stewart, A. F. R., Barbalic, M., Gieger, C., Absher, D., Aherrahrou, Z., Allayee, H., Altshuler, D., Anand, S. S., Andersen, K., Anderson, J. L., Ardissino, D., Ball, S. G., ... Samani, N. J. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics, 43(4), 333-U153. https://doi.org/10.1038/ng.784

@article{6c3277994a7a4a1e80034b89d6040041,

title = "Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease",

abstract = "We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.",

author = "H. Schunkert and I.R. Konig and S. Kathiresan and M.P. Reilly and T.L. Assimes and H. Holm and M. Preuss and A.F.R. Stewart and M. Barbalic and C. Gieger and D. Absher and Z. Aherrahrou and H. Allayee and D. Altshuler and S.S. Anand and K. Andersen and J.L. Anderson and D. Ardissino and S.G. Ball and A.J. Balmforth and T.A. Barnes and D.M. Becker and L.C. Becker and K. Berger and J.C. Bis and S.M. Boekholdt and E. Boerwinkle and P.S. Braund and M.J. Brown and M.S. Burnett and I. Buysschaert and J.F. Carlquist and L. Chen and S. Cichon and V. Codd and R.W. Davies and G. Dedoussis and A. Dehghan and S. Demissie and J.M. Devaney and P. Diemert and R. Do and A. Doering and S. Eifert and {El Mokhtari}, N.E. and S.G. Ellis and R. Elosua and J.C. Engert and S.E. Epstein and {De Faire}, U. and M. Fischer and A.R. Folsom and J. Freyer and B. Gigante and D. Girelli and S. Gretarsdottir and V. Gudnason and J.R. Gulcher and E. Halperin and N. Hammond and S.L. Hazen and A. Hofman and B.D. Horne and T. Illig and C. Iribarren and G.T. Jones and J.W. Jukema and M.A. Kaiser and L.M. Kaplan and J.J.P. Kastelein and K.T. Khaw and J.W. Knowles and G. Kolovou and A. Kong and R. Laaksonen and D. Lambrechts and K. Leander and G. Lettre and M.Y. Li and W. Lieb and C. Loley and A.J. Lotery and P.M. Mannucci and S. Maouche and N. Martinelli and Pascal McKeown and C. Meisinger and T. Meitinger and O. Melander and P.A. Merlini and V. Mooser and T. Morgan and T.W. Muhleisen and J.B. Muhlestein and T. Munzel and K. Musunuru and J. Nahrstaedt and C.P. Nelson and M.M. Nothen and O. Olivieri and R.S. Patel and Christopher Patterson and A. Peters and F. Peyvandi and L. Qu and A.A. Quyyumi and D.J. Rader and L.S. Rallidis and C. Rice and F.R. Rosendaal and D. Rubin and V. Salomaa and M.L. Sampietro and M.S. Sandhu and E. Schadt and A. Schafer and A. Schillert and S. Schreiber and J. Schrezenmeir and S.M. Schwartz and D.S. Siscovick and M. Sivananthan and S. Sivapalaratnam and A. Smith and T.B. Smith and J.D. Snoep and N. Soranzo and J.A. Spertus and K. Stark and K. Stirrups and M. Stoll and W.H.W. Tang and S. Tennstedt and G. Thorgeirsson and G. Thorleifsson and M. Tomaszewski and A.G. Uitterlinden and {Van Rij}, A.M. and B.F. Voight and N.J. Wareham and G.A. Wells and H.E. Wichmann and P.S. Wild and C. Willenborg and J.C.M. Witteman and B.J. Wright and S. Ye and T. Zeller and A. Ziegler and F. Cambien and A.H. Goodall and L.A. Cupples and T. Quertermous and W. Marz and C. Hengstenberg and S. Blankenberg and W.H. Ouwehand and A.S. Hall and P. Deloukas and J.R. Thompson and K. Stefansson and R. Roberts and U. Thorsteinsdottir and C.J. O'Donnell and Ruth McPherson and J. Erdmann and N.J. Samani",

year = "2011",

month = apr,

doi = "10.1038/ng.784",

language = "English",

volume = "43",

pages = "333--U153",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "4",

}

Schunkert, H, Konig, IR, Kathiresan, S, Reilly, MP, Assimes, TL, Holm, H, Preuss, M, Stewart, AFR, Barbalic, M, Gieger, C, Absher, D, Aherrahrou, Z, Allayee, H, Altshuler, D, Anand, SS, Andersen, K, Anderson, JL, Ardissino, D, Ball, SG, Balmforth, AJ, Barnes, TA, Becker, DM, Becker, LC, Berger, K, Bis, JC, Boekholdt, SM, Boerwinkle, E, Braund, PS, Brown, MJ, Burnett, MS, Buysschaert, I, Carlquist, JF, Chen, L, Cichon, S, Codd, V, Davies, RW, Dedoussis, G, Dehghan, A, Demissie, S, Devaney, JM, Diemert, P, Do, R, Doering, A, Eifert, S, El Mokhtari, NE, Ellis, SG, Elosua, R, Engert, JC, Epstein, SE, De Faire, U, Fischer, M, Folsom, AR, Freyer, J, Gigante, B, Girelli, D, Gretarsdottir, S, Gudnason, V, Gulcher, JR, Halperin, E, Hammond, N, Hazen, SL, Hofman, A, Horne, BD, Illig, T, Iribarren, C, Jones, GT, Jukema, JW, Kaiser, MA, Kaplan, LM, Kastelein, JJP, Khaw, KT, Knowles, JW, Kolovou, G, Kong, A, Laaksonen, R, Lambrechts, D, Leander, K, Lettre, G, Li, MY, Lieb, W, Loley, C, Lotery, AJ, Mannucci, PM, Maouche, S, Martinelli, N, McKeown, P, Meisinger, C, Meitinger, T, Melander, O, Merlini, PA, Mooser, V, Morgan, T, Muhleisen, TW, Muhlestein, JB, Munzel, T, Musunuru, K, Nahrstaedt, J, Nelson, CP, Nothen, MM, Olivieri, O, Patel, RS, Patterson, C, Peters, A, Peyvandi, F, Qu, L, Quyyumi, AA, Rader, DJ, Rallidis, LS, Rice, C, Rosendaal, FR, Rubin, D, Salomaa, V, Sampietro, ML, Sandhu, MS, Schadt, E, Schafer, A, Schillert, A, Schreiber, S, Schrezenmeir, J, Schwartz, SM, Siscovick, DS, Sivananthan, M, Sivapalaratnam, S, Smith, A, Smith, TB, Snoep, JD, Soranzo, N, Spertus, JA, Stark, K, Stirrups, K, Stoll, M, Tang, WHW, Tennstedt, S, Thorgeirsson, G, Thorleifsson, G, Tomaszewski, M, Uitterlinden, AG, Van Rij, AM, Voight, BF, Wareham, NJ, Wells, GA, Wichmann, HE, Wild, PS, Willenborg, C, Witteman, JCM, Wright, BJ, Ye, S, Zeller, T, Ziegler, A, Cambien, F, Goodall, AH, Cupples, LA, Quertermous, T, Marz, W, Hengstenberg, C, Blankenberg, S, Ouwehand, WH, Hall, AS, Deloukas, P, Thompson, JR, Stefansson, K, Roberts, R, Thorsteinsdottir, U, O'Donnell, CJ, McPherson, R, Erdmann, J & Samani, NJ 2011, 'Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease', Nature Genetics, vol. 43, no. 4, pp. 333-U153. https://doi.org/10.1038/ng.784

TY - JOUR

T1 - Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

AU - Schunkert, H.

AU - Konig, I.R.

AU - Kathiresan, S.

AU - Reilly, M.P.

AU - Assimes, T.L.

AU - Holm, H.

AU - Preuss, M.

AU - Stewart, A.F.R.

AU - Barbalic, M.

AU - Gieger, C.

AU - Absher, D.

AU - Aherrahrou, Z.

AU - Allayee, H.

AU - Altshuler, D.

AU - Anand, S.S.

AU - Andersen, K.

AU - Anderson, J.L.

AU - Ardissino, D.

AU - Ball, S.G.

AU - Balmforth, A.J.

AU - Barnes, T.A.

AU - Becker, D.M.

AU - Becker, L.C.

AU - Berger, K.

AU - Bis, J.C.

AU - Boekholdt, S.M.

AU - Boerwinkle, E.

AU - Braund, P.S.

AU - Brown, M.J.

AU - Burnett, M.S.

AU - Buysschaert, I.

AU - Carlquist, J.F.

AU - Chen, L.

AU - Cichon, S.

AU - Codd, V.

AU - Davies, R.W.

AU - Dedoussis, G.

AU - Dehghan, A.

AU - Demissie, S.

AU - Devaney, J.M.

AU - Diemert, P.

AU - Do, R.

AU - Doering, A.

AU - Eifert, S.

AU - El Mokhtari, N.E.

AU - Ellis, S.G.

AU - Elosua, R.

AU - Engert, J.C.

AU - Epstein, S.E.

AU - De Faire, U.

AU - Fischer, M.

AU - Folsom, A.R.

AU - Freyer, J.

AU - Gigante, B.

AU - Girelli, D.

AU - Gretarsdottir, S.

AU - Gudnason, V.

AU - Gulcher, J.R.

AU - Halperin, E.

AU - Hammond, N.

AU - Hazen, S.L.

AU - Hofman, A.

AU - Horne, B.D.

AU - Illig, T.

AU - Iribarren, C.

AU - Jones, G.T.

AU - Jukema, J.W.

AU - Kaiser, M.A.

AU - Kaplan, L.M.

AU - Kastelein, J.J.P.

AU - Khaw, K.T.

AU - Knowles, J.W.

AU - Kolovou, G.

AU - Kong, A.

AU - Laaksonen, R.

AU - Lambrechts, D.

AU - Leander, K.

AU - Lettre, G.

AU - Li, M.Y.

AU - Lieb, W.

AU - Loley, C.

AU - Lotery, A.J.

AU - Mannucci, P.M.

AU - Maouche, S.

AU - Martinelli, N.

AU - McKeown, Pascal

AU - Meisinger, C.

AU - Meitinger, T.

AU - Melander, O.

AU - Merlini, P.A.

AU - Mooser, V.

AU - Morgan, T.

AU - Muhleisen, T.W.

AU - Muhlestein, J.B.

AU - Munzel, T.

AU - Musunuru, K.

AU - Nahrstaedt, J.

AU - Nelson, C.P.

AU - Nothen, M.M.

AU - Olivieri, O.

AU - Patel, R.S.

AU - Patterson, Christopher

AU - Peters, A.

AU - Peyvandi, F.

AU - Qu, L.

AU - Quyyumi, A.A.

AU - Rader, D.J.

AU - Rallidis, L.S.

AU - Rice, C.

AU - Rosendaal, F.R.

AU - Rubin, D.

AU - Salomaa, V.

AU - Sampietro, M.L.

AU - Sandhu, M.S.

AU - Schadt, E.

AU - Schafer, A.

AU - Schillert, A.

AU - Schreiber, S.

AU - Schrezenmeir, J.

AU - Schwartz, S.M.

AU - Siscovick, D.S.

AU - Sivananthan, M.

AU - Sivapalaratnam, S.

AU - Smith, A.

AU - Smith, T.B.

AU - Snoep, J.D.

AU - Soranzo, N.

AU - Spertus, J.A.

AU - Stark, K.

AU - Stirrups, K.

AU - Stoll, M.

AU - Tang, W.H.W.

AU - Tennstedt, S.

AU - Thorgeirsson, G.

AU - Thorleifsson, G.

AU - Tomaszewski, M.

AU - Uitterlinden, A.G.

AU - Van Rij, A.M.

AU - Voight, B.F.

AU - Wareham, N.J.

AU - Wells, G.A.

AU - Wichmann, H.E.

AU - Wild, P.S.

AU - Willenborg, C.

AU - Witteman, J.C.M.

AU - Wright, B.J.

AU - Ye, S.

AU - Zeller, T.

AU - Ziegler, A.

AU - Cambien, F.

AU - Goodall, A.H.

AU - Cupples, L.A.

AU - Quertermous, T.

AU - Marz, W.

AU - Hengstenberg, C.

AU - Blankenberg, S.

AU - Ouwehand, W.H.

AU - Hall, A.S.

AU - Deloukas, P.

AU - Thompson, J.R.

AU - Stefansson, K.

AU - Roberts, R.

AU - Thorsteinsdottir, U.

AU - O'Donnell, C.J.

AU - McPherson, Ruth

AU - Erdmann, J.

AU - Samani, N.J.

PY - 2011/4

Y1 - 2011/4

N2 - We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

AB - We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

U2 - 10.1038/ng.784

DO - 10.1038/ng.784

M3 - Article

SN - 1061-4036

VL - 43

SP - 333-U153

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Abstract

ASJC Scopus subject areas

UN SDGs

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