Large-scale association analysis identifies new risk loci for coronary artery disease

Panos Deloukas; Stavroula Kanoni; Christina Willenborg; Martin Farrall; Themistocles L Assimes; JR Thompson; Erik Ingelsson; Danish Saleheen; Jeanette Erdmann; Benjamin A Goldstein; Kathleen Stirrups; Inke R König; Jean-Baptiste Cazier; Asa Johansson; Alistair S Hall; Jong-Young Lee; Cristen J Willer; John C Chambers; Tõnu Esko; Lasse Folkersen; Anuj Goel; Elin Grundberg; Aki S Havulinna; Weang K Ho; Jemma C Hopewell; Niclas Eriksson; Marcus E Kleber; Kati Kristiansson; Per Lundmark; Leo-Pekka Lyytikäinen; Suzanne Rafelt; Dmitry Shungin; Rona J Strawbridge; Gudmar Thorleifsson; Emmi Tikkanen; Natalie Van Zuydam; Benjamin F Voight; Lindsay L Waite; Weihua Zhang; Andreas Ziegler; Devin Absher; David Altshuler; Anthony J Balmforth; Inês Barroso; Peter S Braund; Christof Burgdorf; Alun Evans; Frank Kee; Jeong E Park; Rory Collins; CARDIoGRAMplusC4D Consortium

doi:10.1038/ng.2480

Large-scale association analysis identifies new risk loci for coronary artery disease

Panos Deloukas, Stavroula Kanoni, Christina Willenborg, Martin Farrall, Themistocles L Assimes, JR Thompson, Erik Ingelsson, Danish Saleheen, Jeanette Erdmann, Benjamin A Goldstein, Kathleen Stirrups, Inke R König, Jean-Baptiste Cazier, Asa Johansson, Alistair S Hall, Jong-Young Lee, Cristen J Willer, John C Chambers, Tõnu Esko, Lasse FolkersenAnuj Goel, Elin Grundberg, Aki S Havulinna, Weang K Ho, Jemma C Hopewell, Niclas Eriksson, Marcus E Kleber, Kati Kristiansson, Per Lundmark, Leo-Pekka Lyytikäinen, Suzanne Rafelt, Dmitry Shungin, Rona J Strawbridge, Gudmar Thorleifsson, Emmi Tikkanen, Natalie Van Zuydam, Benjamin F Voight, Lindsay L Waite, Weihua Zhang, Andreas Ziegler, Devin Absher, David Altshuler, Anthony J Balmforth, Inês Barroso, Peter S Braund, Christof Burgdorf, Alun Evans, Frank Kee, Jeong E Park, Rory Collins, CARDIoGRAMplusC4D Consortium

Research output: Contribution to journal › Article › peer-review

1000 Citations (Scopus)

Abstract

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2)

Original language	English
Pages (from-to)	25-33
Number of pages	9
Journal	Nature Genetics
Volume	45
Issue number	1
DOIs	https://doi.org/10.1038/ng.2480
Publication status	Published - Jan 2013

Keywords

Adult
Aged
Asian Continental Ancestry Group
Cell Line
Coronary Artery Disease
European Continental Ancestry Group
Female
Gene Regulatory Networks
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Risk Factors

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Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, JR., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, B. A., Stirrups, K., König, I. R., Cazier, J-B., Johansson, A., Hall, A. S., Lee, J-Y., Willer, C. J., Chambers, J. C., Esko, T., ... CARDIoGRAMplusC4D Consortium (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. Nature Genetics, 45(1), 25-33. https://doi.org/10.1038/ng.2480

Deloukas, Panos ; Kanoni, Stavroula ; Willenborg, Christina ; Farrall, Martin ; Assimes, Themistocles L ; Thompson, JR ; Ingelsson, Erik ; Saleheen, Danish ; Erdmann, Jeanette ; Goldstein, Benjamin A ; Stirrups, Kathleen ; König, Inke R ; Cazier, Jean-Baptiste ; Johansson, Asa ; Hall, Alistair S ; Lee, Jong-Young ; Willer, Cristen J ; Chambers, John C ; Esko, Tõnu ; Folkersen, Lasse ; Goel, Anuj ; Grundberg, Elin ; Havulinna, Aki S ; Ho, Weang K ; Hopewell, Jemma C ; Eriksson, Niclas ; Kleber, Marcus E ; Kristiansson, Kati ; Lundmark, Per ; Lyytikäinen, Leo-Pekka ; Rafelt, Suzanne ; Shungin, Dmitry ; Strawbridge, Rona J ; Thorleifsson, Gudmar ; Tikkanen, Emmi ; Van Zuydam, Natalie ; Voight, Benjamin F ; Waite, Lindsay L ; Zhang, Weihua ; Ziegler, Andreas ; Absher, Devin ; Altshuler, David ; Balmforth, Anthony J ; Barroso, Inês ; Braund, Peter S ; Burgdorf, Christof ; Evans, Alun ; Kee, Frank ; Park, Jeong E ; Collins, Rory ; CARDIoGRAMplusC4D Consortium. / Large-scale association analysis identifies new risk loci for coronary artery disease. In: Nature Genetics. 2013 ; Vol. 45, No. 1. pp. 25-33.

@article{224c2a297c2e4af88e16737c9ac69167,

title = "Large-scale association analysis identifies new risk loci for coronary artery disease",

abstract = "Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2) ",

keywords = "Adult, Aged, Asian Continental Ancestry Group, Cell Line, Coronary Artery Disease, European Continental Ancestry Group, Female, Gene Regulatory Networks, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk Factors",

author = "Panos Deloukas and Stavroula Kanoni and Christina Willenborg and Martin Farrall and Assimes, {Themistocles L} and JR Thompson and Erik Ingelsson and Danish Saleheen and Jeanette Erdmann and Goldstein, {Benjamin A} and Kathleen Stirrups and K{\"o}nig, {Inke R} and Jean-Baptiste Cazier and Asa Johansson and Hall, {Alistair S} and Jong-Young Lee and Willer, {Cristen J} and Chambers, {John C} and T{\~o}nu Esko and Lasse Folkersen and Anuj Goel and Elin Grundberg and Havulinna, {Aki S} and Ho, {Weang K} and Hopewell, {Jemma C} and Niclas Eriksson and Kleber, {Marcus E} and Kati Kristiansson and Per Lundmark and Leo-Pekka Lyytik{\"a}inen and Suzanne Rafelt and Dmitry Shungin and Strawbridge, {Rona J} and Gudmar Thorleifsson and Emmi Tikkanen and {Van Zuydam}, Natalie and Voight, {Benjamin F} and Waite, {Lindsay L} and Weihua Zhang and Andreas Ziegler and Devin Absher and David Altshuler and Balmforth, {Anthony J} and In{\^e}s Barroso and Braund, {Peter S} and Christof Burgdorf and Alun Evans and Frank Kee and Park, {Jeong E} and Rory Collins and {CARDIoGRAMplusC4D Consortium}",

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month = jan,

doi = "10.1038/ng.2480",

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Deloukas, P, Kanoni, S, Willenborg, C, Farrall, M, Assimes, TL, Thompson, JR, Ingelsson, E, Saleheen, D, Erdmann, J, Goldstein, BA, Stirrups, K, König, IR, Cazier, J-B, Johansson, A, Hall, AS, Lee, J-Y, Willer, CJ, Chambers, JC, Esko, T, Folkersen, L, Goel, A, Grundberg, E, Havulinna, AS, Ho, WK, Hopewell, JC, Eriksson, N, Kleber, ME, Kristiansson, K, Lundmark, P, Lyytikäinen, L-P, Rafelt, S, Shungin, D, Strawbridge, RJ, Thorleifsson, G, Tikkanen, E, Van Zuydam, N, Voight, BF, Waite, LL, Zhang, W, Ziegler, A, Absher, D, Altshuler, D, Balmforth, AJ, Barroso, I, Braund, PS, Burgdorf, C, Evans, A, Kee, F , Park, JE, Collins, R & CARDIoGRAMplusC4D Consortium 2013, 'Large-scale association analysis identifies new risk loci for coronary artery disease', Nature Genetics, vol. 45, no. 1, pp. 25-33. https://doi.org/10.1038/ng.2480

Large-scale association analysis identifies new risk loci for coronary artery disease. / Deloukas, Panos; Kanoni, Stavroula; Willenborg, Christina; Farrall, Martin; Assimes, Themistocles L; Thompson, JR; Ingelsson, Erik; Saleheen, Danish; Erdmann, Jeanette; Goldstein, Benjamin A; Stirrups, Kathleen; König, Inke R; Cazier, Jean-Baptiste; Johansson, Asa; Hall, Alistair S; Lee, Jong-Young; Willer, Cristen J; Chambers, John C; Esko, Tõnu; Folkersen, Lasse; Goel, Anuj; Grundberg, Elin; Havulinna, Aki S; Ho, Weang K; Hopewell, Jemma C; Eriksson, Niclas; Kleber, Marcus E; Kristiansson, Kati; Lundmark, Per; Lyytikäinen, Leo-Pekka; Rafelt, Suzanne; Shungin, Dmitry; Strawbridge, Rona J; Thorleifsson, Gudmar; Tikkanen, Emmi; Van Zuydam, Natalie; Voight, Benjamin F; Waite, Lindsay L; Zhang, Weihua; Ziegler, Andreas; Absher, Devin; Altshuler, David; Balmforth, Anthony J; Barroso, Inês; Braund, Peter S; Burgdorf, Christof; Evans, Alun; Kee, Frank ; Park, Jeong E; Collins, Rory; CARDIoGRAMplusC4D Consortium.

In: Nature Genetics, Vol. 45, No. 1, 01.2013, p. 25-33.

Research output: Contribution to journal › Article › peer-review

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T1 - Large-scale association analysis identifies new risk loci for coronary artery disease

AU - Deloukas, Panos

AU - Kanoni, Stavroula

AU - Willenborg, Christina

AU - Farrall, Martin

AU - Assimes, Themistocles L

AU - Thompson, JR

AU - Ingelsson, Erik

AU - Saleheen, Danish

AU - Erdmann, Jeanette

AU - Goldstein, Benjamin A

AU - Stirrups, Kathleen

AU - König, Inke R

AU - Cazier, Jean-Baptiste

AU - Johansson, Asa

AU - Hall, Alistair S

AU - Lee, Jong-Young

AU - Willer, Cristen J

AU - Chambers, John C

AU - Esko, Tõnu

AU - Folkersen, Lasse

AU - Goel, Anuj

AU - Grundberg, Elin

AU - Havulinna, Aki S

AU - Ho, Weang K

AU - Hopewell, Jemma C

AU - Eriksson, Niclas

AU - Kleber, Marcus E

AU - Kristiansson, Kati

AU - Lundmark, Per

AU - Lyytikäinen, Leo-Pekka

AU - Rafelt, Suzanne

AU - Shungin, Dmitry

AU - Strawbridge, Rona J

AU - Thorleifsson, Gudmar

AU - Tikkanen, Emmi

AU - Van Zuydam, Natalie

AU - Voight, Benjamin F

AU - Waite, Lindsay L

AU - Zhang, Weihua

AU - Ziegler, Andreas

AU - Absher, Devin

AU - Altshuler, David

AU - Balmforth, Anthony J

AU - Barroso, Inês

AU - Braund, Peter S

AU - Burgdorf, Christof

AU - Evans, Alun

AU - Kee, Frank

AU - Park, Jeong E

AU - Collins, Rory

AU - CARDIoGRAMplusC4D Consortium

PY - 2013/1

Y1 - 2013/1

N2 - Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2)

AB - Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2)

KW - Adult

KW - Aged

KW - Asian Continental Ancestry Group

KW - Cell Line

KW - Coronary Artery Disease

KW - European Continental Ancestry Group

KW - Female

KW - Gene Regulatory Networks

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

KW - Risk Factors

U2 - 10.1038/ng.2480

DO - 10.1038/ng.2480

M3 - Article

C2 - 23202125

VL - 45

SP - 25

EP - 33

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 1

ER -