Laser-driven electron source suitable for   of biological cells at dose rates exceeding 1010 Gy/s

C. A. McAnespie; P. Chaudhary; L. Calvin; M. J. V. Streeter; G. Nersysian; S. J. McMahon; K. M. Prise; G. Sarri

doi:10.1103/physreve.110.035204

Laser-driven electron source suitable for of biological cells at dose rates exceeding 10¹⁰ Gy/s

C. A. McAnespie, P. Chaudhary, L. Calvin, M. J. V. Streeter, G. Nersysian, S. J. McMahon, K. M. Prise, G. Sarri

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Abstract

We report on the first systematic characterization of a tuneable laser-driven electron source capable of delivering Gy-scale doses in a duration of 10–20 ps in a single irradiation, thus reaching unprecedented dose rates in the range of 1010–1012 Gy/s. Detailed characterization of the source indicates, in agreement with Monte Carlo simulations, dose delivery over cm-scale areas with a high degree of spatial uniformity. The results reported here confirm that a laser-driven source of this kind can be used for systematic studies of the response of biological cells to picosecond-scale radiation at ultrahigh dose rates.

Original language	English
Article number	035204
Journal	Physical Review E
Volume	110
Issue number	3
Early online date	12 Sept 2024
DOIs	https://doi.org/10.1103/physreve.110.035204
Publication status	Early online date - 12 Sept 2024

Keywords

Laser-driven electron source
single-shot Gy-scale irradiation
Gy-scale irradiation
Gy-scale

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10.1103/physreve.110.035204Licence: CC BY

Laser-driven electron source suitable for single-shot Gy-scale irradiation of biological cells at dose rates exceeding 1010 Gy/s
Copyright 2024 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.76 MBLicence: CC BY

Cite this

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title = "Laser-driven electron source suitable for of biological cells at dose rates exceeding 1010 Gy/s",

abstract = "We report on the first systematic characterization of a tuneable laser-driven electron source capable of delivering Gy-scale doses in a duration of 10–20 ps in a single irradiation, thus reaching unprecedented dose rates in the range of 1010–1012 Gy/s. Detailed characterization of the source indicates, in agreement with Monte Carlo simulations, dose delivery over cm-scale areas with a high degree of spatial uniformity. The results reported here confirm that a laser-driven source of this kind can be used for systematic studies of the response of biological cells to picosecond-scale radiation at ultrahigh dose rates. ",

keywords = "Laser-driven electron source, single-shot Gy-scale irradiation, Gy-scale irradiation, Gy-scale",

author = "McAnespie, {C. A.} and P. Chaudhary and L. Calvin and Streeter, {M. J. V.} and G. Nersysian and McMahon, {S. J.} and Prise, {K. M.} and G. Sarri",

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doi = "10.1103/physreve.110.035204",

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T1 - Laser-driven electron source suitable for of biological cells at dose rates exceeding 1010 Gy/s

AU - McAnespie, C. A.

AU - Chaudhary, P.

AU - Calvin, L.

AU - Streeter, M. J. V.

AU - Nersysian, G.

AU - McMahon, S. J.

AU - Prise, K. M.

AU - Sarri, G.

PY - 2024/9/12

Y1 - 2024/9/12

N2 - We report on the first systematic characterization of a tuneable laser-driven electron source capable of delivering Gy-scale doses in a duration of 10–20 ps in a single irradiation, thus reaching unprecedented dose rates in the range of 1010–1012 Gy/s. Detailed characterization of the source indicates, in agreement with Monte Carlo simulations, dose delivery over cm-scale areas with a high degree of spatial uniformity. The results reported here confirm that a laser-driven source of this kind can be used for systematic studies of the response of biological cells to picosecond-scale radiation at ultrahigh dose rates.

AB - We report on the first systematic characterization of a tuneable laser-driven electron source capable of delivering Gy-scale doses in a duration of 10–20 ps in a single irradiation, thus reaching unprecedented dose rates in the range of 1010–1012 Gy/s. Detailed characterization of the source indicates, in agreement with Monte Carlo simulations, dose delivery over cm-scale areas with a high degree of spatial uniformity. The results reported here confirm that a laser-driven source of this kind can be used for systematic studies of the response of biological cells to picosecond-scale radiation at ultrahigh dose rates.

KW - Laser-driven electron source

KW - single-shot Gy-scale irradiation

KW - Gy-scale irradiation

KW - Gy-scale

U2 - 10.1103/physreve.110.035204

DO - 10.1103/physreve.110.035204

M3 - Article

SN - 2470-0045

VL - 110

JO - Physical Review E

JF - Physical Review E

IS - 3

M1 - 035204

ER -

Laser-driven electron source suitable for of biological cells at dose rates exceeding 1010 Gy/s

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Keywords

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Laser-driven electron source suitable for of biological cells at dose rates exceeding 10¹⁰ Gy/s