LC- HRMS based metabolomics in food safety and doping control – DeTECH21

Anna Gadaj, Gaud Dervilly-Pinel, Bruno LeBizec, Christopher T. Elliott, Alex J. Raeber, Tom Buckley, Ray MacSharry, Marie-Agnes Popot, Yves Bonnaire, Mark H. Mooney, Mark Sherry

Research output: Contribution to conferencePoster

Abstract

Issues surrounding the misuse of prohibited and licensed substances in animals destined for food production and performance sport competition continue to be an enormous challenge to regulatory authorities charged with enforcing their control. Efficient analytical strategies are implemented to screen and confirm the presence of a wide range of exogenous substances in various biological matrices. However, such methods rely on the direct measurement of drugs and/or their metabolites in a targeted mode, allowing the detection of restricted number of compounds. As a consequence, emerging practices, in particular the use of natural hormones, designer drugs and low-dose cocktails, remain difficult to handle from a control point of view. A new SME-led FP7 funded project, DeTECH21, aims to overcome current limitations by applying an untargeted metabolomics approach based on liquid chromatography coupled to high resolution mass spectrometry and bioinformatic data analysis to identify bovine and equine animals which have been exposed to exogenous substances and assist in the identification of administered compounds. Markerbased strategies, dealing with the comprehensive analysis of metabolites present in a biological sample (urine/plasma/tissue), offer a reliable solution in the areas of food safety and animal sport doping control by effective, high-throughput and sensitive detection of exogenously administered agents. Therefore, the development of the first commercially available forensic test service based on metabolomics profiling will meet 21st century demands in animal forensics.
Original languageEnglish
Publication statusPublished - 10 Apr 2014
EventASSET 2014: Food Integrity and Traceability Conference - Queen's University Belfast, Belfast, United Kingdom
Duration: 08 Apr 201410 Apr 2014

Conference

ConferenceASSET 2014: Food Integrity and Traceability Conference
CountryUnited Kingdom
CityBelfast
Period08/04/201410/04/2014

Bibliographical note

Poster 65

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    Gadaj, A., Dervilly-Pinel, G., LeBizec, B., Elliott, C. T., Raeber, A. J., Buckley, T., MacSharry, R., Popot, M-A., Bonnaire, Y., Mooney, M. H., & Sherry, M. (2014). LC- HRMS based metabolomics in food safety and doping control – DeTECH21. Poster session presented at ASSET 2014: Food Integrity and Traceability Conference, Belfast, United Kingdom. http://www.qub.ac.uk/asset2014/booklet.html