LDL-containing immune complexes in the DCCT/EDIC cohort: associations with lipoprotein subclasses

Richard L Klein, Rickey E Carter, Alicia J Jenkins, Timothy J Lyons, Nathaniel L Baker, Gregory E Gilbert, Gabriel Virella, Maria F Lopes-Virella, DCCT/EDIC Research Group

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7 Citations (Scopus)

Abstract

Immune complexes containing modified LDL (LDL-IC) and NMR-determined Total LDL particle concentrations are significantly associated with intima-media thickness (IMT). We analyzed the associations between concentrations of NMR-determined lipoprotein subclasses and LDL-IC in the DCCT/EDIC cohort. LDL-IC concentrations in women and men of the DCCT/EDIC cohort did not differ significantly and were positively associated with Total LDL particle concentrations in men and women (r=0.34, r=0.32, respectively; P
Original languageEnglish
Pages (from-to)73-82
Number of pages10
JournalJournal of diabetes and its complications
Volume25
Issue number2
DOIs
Publication statusPublished - 2011

Bibliographical note

Published by Elsevier Inc.

Keywords

  • Adult
  • Antigen-Antibody Complex
  • Blood Chemical Analysis
  • Clinical Trials as Topic
  • Cohort Studies
  • Diabetes Complications
  • Diabetes Mellitus, Type 1
  • Female
  • Humans
  • Lipoproteins, LDL
  • Male
  • Middle Aged
  • Nuclear Magnetic Resonance, Biomolecular
  • Osmolar Concentration
  • Particle Size
  • Sex Characteristics

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    Klein, R. L., Carter, R. E., Jenkins, A. J., Lyons, T. J., Baker, N. L., Gilbert, G. E., Virella, G., Lopes-Virella, M. F., & DCCT/EDIC Research Group (2011). LDL-containing immune complexes in the DCCT/EDIC cohort: associations with lipoprotein subclasses. Journal of diabetes and its complications, 25(2), 73-82. https://doi.org/10.1016/j.jdiacomp.2010.03.001