LDL-containing immune complexes in the DCCT/EDIC cohort: associations with lipoprotein subclasses

Richard L Klein; Rickey E Carter; Alicia J Jenkins; Timothy J Lyons; Nathaniel L Baker; Gregory E Gilbert; Gabriel Virella; Maria F Lopes-Virella; DCCT/EDIC Research Group

doi:10.1016/j.jdiacomp.2010.03.001

LDL-containing immune complexes in the DCCT/EDIC cohort: associations with lipoprotein subclasses

Richard L Klein, Rickey E Carter, Alicia J Jenkins, Timothy J Lyons, Nathaniel L Baker, Gregory E Gilbert, Gabriel Virella, Maria F Lopes-Virella, DCCT/EDIC Research Group

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Immune complexes containing modified LDL (LDL-IC) and NMR-determined Total LDL particle concentrations are significantly associated with intima-media thickness (IMT). We analyzed the associations between concentrations of NMR-determined lipoprotein subclasses and LDL-IC in the DCCT/EDIC cohort. LDL-IC concentrations in women and men of the DCCT/EDIC cohort did not differ significantly and were positively associated with Total LDL particle concentrations in men and women (r=0.34, r=0.32, respectively; P

Original language	English
Pages (from-to)	73-82
Number of pages	10
Journal	Journal of diabetes and its complications
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/j.jdiacomp.2010.03.001
Publication status	Published - 2011

Bibliographical note

Published by Elsevier Inc.

Keywords

Adult
Antigen-Antibody Complex
Blood Chemical Analysis
Clinical Trials as Topic
Cohort Studies
Diabetes Complications
Diabetes Mellitus, Type 1
Female
Humans
Lipoproteins, LDL
Male
Middle Aged
Nuclear Magnetic Resonance, Biomolecular
Osmolar Concentration
Particle Size
Sex Characteristics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jdiacomp.2010.03.001

Cite this

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title = "LDL-containing immune complexes in the DCCT/EDIC cohort: associations with lipoprotein subclasses",

abstract = "Immune complexes containing modified LDL (LDL-IC) and NMR-determined Total LDL particle concentrations are significantly associated with intima-media thickness (IMT). We analyzed the associations between concentrations of NMR-determined lipoprotein subclasses and LDL-IC in the DCCT/EDIC cohort. LDL-IC concentrations in women and men of the DCCT/EDIC cohort did not differ significantly and were positively associated with Total LDL particle concentrations in men and women (r=0.34, r=0.32, respectively; P",

keywords = "Adult, Antigen-Antibody Complex, Blood Chemical Analysis, Clinical Trials as Topic, Cohort Studies, Diabetes Complications, Diabetes Mellitus, Type 1, Female, Humans, Lipoproteins, LDL, Male, Middle Aged, Nuclear Magnetic Resonance, Biomolecular, Osmolar Concentration, Particle Size, Sex Characteristics",

author = "Klein, {Richard L} and Carter, {Rickey E} and Jenkins, {Alicia J} and Lyons, {Timothy J} and Baker, {Nathaniel L} and Gilbert, {Gregory E} and Gabriel Virella and Lopes-Virella, {Maria F} and {DCCT/EDIC Research Group}",

note = "Published by Elsevier Inc.",

year = "2011",

doi = "10.1016/j.jdiacomp.2010.03.001",

language = "English",

volume = "25",

pages = "73--82",

journal = "Journal of diabetes and its complications",

issn = "1056-8727",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - LDL-containing immune complexes in the DCCT/EDIC cohort

T2 - associations with lipoprotein subclasses

AU - Klein, Richard L

AU - Carter, Rickey E

AU - Jenkins, Alicia J

AU - Lyons, Timothy J

AU - Baker, Nathaniel L

AU - Gilbert, Gregory E

AU - Virella, Gabriel

AU - Lopes-Virella, Maria F

AU - DCCT/EDIC Research Group

N1 - Published by Elsevier Inc.

PY - 2011

Y1 - 2011

N2 - Immune complexes containing modified LDL (LDL-IC) and NMR-determined Total LDL particle concentrations are significantly associated with intima-media thickness (IMT). We analyzed the associations between concentrations of NMR-determined lipoprotein subclasses and LDL-IC in the DCCT/EDIC cohort. LDL-IC concentrations in women and men of the DCCT/EDIC cohort did not differ significantly and were positively associated with Total LDL particle concentrations in men and women (r=0.34, r=0.32, respectively; P

AB - Immune complexes containing modified LDL (LDL-IC) and NMR-determined Total LDL particle concentrations are significantly associated with intima-media thickness (IMT). We analyzed the associations between concentrations of NMR-determined lipoprotein subclasses and LDL-IC in the DCCT/EDIC cohort. LDL-IC concentrations in women and men of the DCCT/EDIC cohort did not differ significantly and were positively associated with Total LDL particle concentrations in men and women (r=0.34, r=0.32, respectively; P

KW - Adult

KW - Antigen-Antibody Complex

KW - Blood Chemical Analysis

KW - Clinical Trials as Topic

KW - Cohort Studies

KW - Diabetes Complications

KW - Diabetes Mellitus, Type 1

KW - Female

KW - Humans

KW - Lipoproteins, LDL

KW - Male

KW - Middle Aged

KW - Nuclear Magnetic Resonance, Biomolecular

KW - Osmolar Concentration

KW - Particle Size

KW - Sex Characteristics

U2 - 10.1016/j.jdiacomp.2010.03.001

DO - 10.1016/j.jdiacomp.2010.03.001

M3 - Article

C2 - 20605479

SN - 1056-8727

VL - 25

SP - 73

EP - 82

JO - Journal of diabetes and its complications

JF - Journal of diabetes and its complications

IS - 2

ER -

LDL-containing immune complexes in the DCCT/EDIC cohort: associations with lipoprotein subclasses

Abstract

Bibliographical note

Keywords

UN SDGs

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