Light Triggered Nitric Oxide Release from N-Nitroso Porous Organic Polymers

Sharon Gregg, Rene-Ponce Nze, Bo Xiao

Research output: Contribution to conferencePosterpeer-review

Abstract

Nitric oxide (NO) deficiency caused by ageing or disease such as diabetes can result in chronic, non-healing wounds and an increased risk of infection. Direct delivery of NO to a wound site can promote healing and antimicrobial action. As a potential topical therapeutic agent, its effectiveness significantly relies on NO gas delivery methods capable of delivering the desired amount of NO to the targets effectively. N-nitrosamine and N-diazeniumdiolate NO-donor groups have received much attention recently, as they can release NO in response to external stimuli such as light irradiation, pH and temperature. Control over NO release by incorporating NO-donor groups into carrier materials such as polymers or silica nanoparticles has been employed in an attempt to achieve targeted delivery and extended release duration. We have developed porous organic polymers with dihydropyridine moieties and BET surface areas ranging 67- 430 m2g-1. Solid state 13C NMR and FTIR were employed to characterise polymer structures, and the conversion of >NH to >N-NO was identified by characteristic IR bands at ~ 1500 cm-1 and 970 cm-1. The N-nitroso moiety is light sensitive and exposure to light irradiation (365 nm) releases NO in aqueous solution. The Griess method was used for the determination of NO released over time.5
Original languageEnglish
Publication statusPublished - 12 Jul 2017
EventThe 13th International Conference on Materials Chemistry - ACC Liverpool, Liverpool, United Kingdom
Duration: 10 Jul 201713 Jul 2017
Conference number: MC13

Conference

ConferenceThe 13th International Conference on Materials Chemistry
CountryUnited Kingdom
CityLiverpool
Period10/07/201713/07/2017

Keywords

  • bioactive nitric oxide

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