Lighting-up Protein-Ligand Interactions with Fluorescent PET (Photoinduced Electron Transfer) Sensor Designs

Bernard McLaughlin; A. Prasanna de Silva; Glenn D. Wright; Brian Daly; Esther M. Surender

doi:10.1039/C7CC05929A

Lighting-up Protein-Ligand Interactions with Fluorescent PET (Photoinduced Electron Transfer) Sensor Designs

Bernard McLaughlin
, A. Prasanna de Silva
, Glenn D. Wright
, Brian Daly
, Esther M. Surender

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

497 Downloads (Pure)

Abstract

The fluorescence of sensors 1 and 6, which are designed in terms of photoinduced electron transfer (PET), are switched ‘on’ by factors of 15 and 6 with avidin in a rather selective manner. 3 and 7, simpler derivatives of 1, are switched ‘on’ by factors of 16 and 7.5 with bovine serum albumin, though at 30-fold higher concentrations.

Original language	English
Pages (from-to)	1319
Number of pages	5
Journal	Chemical Communications
Volume	54
Early online date	27 Nov 2017
DOIs	https://doi.org/10.1039/C7CC05929A
Publication status	Early online date - 27 Nov 2017

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10.1039/C7CC05929ALicence: Unspecified

Lighting‐up Protein‐Ligand Interactions with Fluorescent PET (Photoinduced Electron Transfer) Sensor Designs
© 2017 Royal Society of Chemistry. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 242 KBLicence: Unspecified

Amilra De Silva
- a.desilvaqub.acuk
- School of Chemistry and Chemical Engineering - Emeritus Professor
- Sensors
Person: Emeritus

Cite this

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title = "Lighting-up Protein-Ligand Interactions with Fluorescent PET (Photoinduced Electron Transfer) Sensor Designs",

abstract = "The fluorescence of sensors 1 and 6, which are designed in terms of photoinduced electron transfer (PET), are switched {\textquoteleft}on{\textquoteright} by factors of 15 and 6 with avidin in a rather selective manner. 3 and 7, simpler derivatives of 1, are switched {\textquoteleft}on{\textquoteright} by factors of 16 and 7.5 with bovine serum albumin, though at 30-fold higher concentrations. ",

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AU - McLaughlin, Bernard

AU - de Silva, A. Prasanna

AU - Wright, Glenn D.

AU - Daly, Brian

AU - Surender, Esther M.

PY - 2017/11/27

Y1 - 2017/11/27

N2 - The fluorescence of sensors 1 and 6, which are designed in terms of photoinduced electron transfer (PET), are switched ‘on’ by factors of 15 and 6 with avidin in a rather selective manner. 3 and 7, simpler derivatives of 1, are switched ‘on’ by factors of 16 and 7.5 with bovine serum albumin, though at 30-fold higher concentrations.

AB - The fluorescence of sensors 1 and 6, which are designed in terms of photoinduced electron transfer (PET), are switched ‘on’ by factors of 15 and 6 with avidin in a rather selective manner. 3 and 7, simpler derivatives of 1, are switched ‘on’ by factors of 16 and 7.5 with bovine serum albumin, though at 30-fold higher concentrations.

U2 - 10.1039/C7CC05929A

DO - 10.1039/C7CC05929A

M3 - Article

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VL - 54

SP - 1319

JO - Chemical Communications

JF - Chemical Communications

ER -

Lighting-up Protein-Ligand Interactions with Fluorescent PET (Photoinduced Electron Transfer) Sensor Designs

Abstract

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Amilra De Silva

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