Limitations of Gene Duplication Models: Evolution of Modules in Protein Interaction Networks

Frank Emmert-Streib

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
209 Downloads (Pure)

Abstract

It has been generally acknowledged that the module structure of protein interaction networks plays a crucial role with respect to the functional understanding of these networks. In this paper, we study evolutionary aspects of the module structure of protein interaction networks, which forms a mesoscopic level of description with respect to the architectural principles of networks. The purpose of this paper is to investigate limitations of well known gene duplication models by showing that these models are lacking crucial structural features present in protein interaction networks on a mesoscopic scale. This observation reveals our incomplete understanding of the structural evolution of protein networks on the module level. © 2012 Emmert-Streib.

Original languageEnglish
Article numbere35531
Pages (from-to)1-13
Number of pages13
JournalPLoS ONE
Volume7
Issue number4
DOIs
Publication statusPublished - 18 Apr 2012

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Limitations of Gene Duplication Models: Evolution of Modules in Protein Interaction Networks'. Together they form a unique fingerprint.

Cite this