Linking processing, microstructure and mechanical properties of expanded PLLA tubes for bioresorbable stent applications

Lison Rocher; Jude Cameron; Jordan Barr; Brian Dillon; Alex B. Lennon; Gary H. Menary

doi:10.1016/j.eurpolymj.2023.112205

Linking processing, microstructure and mechanical properties of expanded PLLA tubes for bioresorbable stent applications

Lison Rocher
, Jude Cameron
, Jordan Barr
, Brian Dillon
, Alex B. Lennon^*
, Gary H. Menary

^*Corresponding author for this work

School of Mechanical and Aerospace Engineering

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

156 Downloads (Pure)

Abstract

Bioresorbable poly-L-lactide (PLLA) stents have the potential to fully dissolve after treating injured arteries, leaving nothing behind. However, the manufacturing process for bioresorbable stents (BRS) needs further refinement to eventually replace current permanent stents. This study investigates the effect of radial and biaxial expansion procedures on the microstructure and mechanical properties of PLLA expanded tubes using microfocus wide -angle X-ray scattering (WAXS) and multi-directional tensile tests. A complex microstructure with an orientation gradient across the thickness of the tube wall was observed and linked to the strain history experienced during processing. Correlations between the stretch ratios applied and the mechanical properties of the PLLA tubes were also noted and discussed in relation to stent application.

Original language	English
Article number	112205
Number of pages	11
Journal	European Polymer Journal
Volume	195
Early online date	19 Jun 2023
DOIs	https://doi.org/10.1016/j.eurpolymj.2023.112205
Publication status	Published - 17 Aug 2023

Keywords

biaxial expansion
bioresorbable stents
mechanical properties
microfocus WAXS
microstructure
poly-L-lactide

ASJC Scopus subject areas

General Physics and Astronomy
Polymers and Plastics
Organic Chemistry
Materials Chemistry

Access to Document

10.1016/j.eurpolymj.2023.112205Licence: CC BY-NC-ND

Linking processing, microstructure and mechanical properties of expanded PLLA tubes for bioresorbable stent applications
Copyright 2023 The Authors. This is an open access article published under a Creative Commons Attribution-NonCommercial-NoDerivatives License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.
Final published version, 7.62 MBLicence: CC BY-NC-ND

Exploring the structure-processing-property relationships of Poly(l-lactic acid) in bioresorbable vascular scaffolds using high resolution characterisation
Cameron, J. (Author), Lennon, A. (Supervisor) & Menary, G. (Supervisor), Jul 2025
Student thesis: Doctoral Thesis › Doctor of Philosophy
Investigating crimping and deployment of poly(L-lactic acid) bioresorbable vascular scaffolds: unravelling their impact on scaffold performance in the context of overall processing history
Barr, J. J. (Author), Lennon, A. (Supervisor) & Menary, G. (Supervisor), Dec 2024
Student thesis: Doctoral Thesis › Doctor of Philosophy
Investigation of the effect of nanoparticle addition and processing history on Poly(l-lactide) stent properties
Rocher, L. (Author), Lennon, A. (Supervisor), Menary, G. (Supervisor) & Dillon, B. (Supervisor), Dec 2023
Student thesis: Doctoral Thesis › Doctor of Philosophy

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12 Citations
1 Article

Interaction of Poly L-Lactide and Tungsten Disulfide Nanotubes Studied by in Situ X-ray Scattering during Expansion of PLLA/WS2NT Nanocomposite Tubes
Rocher, L., Ylitalo, A. S., Di Luccio, T., Miscioscia, R., De Filippo, G., Pandolfi, G., Villani, F., Zak, A., Menary, G. H., Lennon, A. B. & Kornfield, J. A., 27 May 2021, In: Polymers. 13, 11, 19 p., 1764.
Research output: Contribution to journal › Article › peer-review

Open Access
File
9 Link opens in a new tab Citations (Scopus)

182 Downloads (Pure)

Cite this

@article{bf8ed55e87c744388fefac26e2ab04b0,

title = "Linking processing, microstructure and mechanical properties of expanded PLLA tubes for bioresorbable stent applications",

abstract = "Bioresorbable poly-L-lactide (PLLA) stents have the potential to fully dissolve after treating injured arteries, leaving nothing behind. However, the manufacturing process for bioresorbable stents (BRS) needs further refinement to eventually replace current permanent stents. This study investigates the effect of radial and biaxial expansion procedures on the microstructure and mechanical properties of PLLA expanded tubes using microfocus wide -angle X-ray scattering (WAXS) and multi-directional tensile tests. A complex microstructure with an orientation gradient across the thickness of the tube wall was observed and linked to the strain history experienced during processing. Correlations between the stretch ratios applied and the mechanical properties of the PLLA tubes were also noted and discussed in relation to stent application. ",

keywords = "biaxial expansion, bioresorbable stents, mechanical properties, microfocus WAXS, microstructure, poly-L-lactide",

author = "Lison Rocher and Jude Cameron and Jordan Barr and Brian Dillon and Lennon, \{Alex B.\} and Menary, \{Gary H.\}",

year = "2023",

month = aug,

day = "17",

doi = "10.1016/j.eurpolymj.2023.112205",

language = "English",

volume = "195",

journal = "European Polymer Journal",

issn = "0014-3057",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Linking processing, microstructure and mechanical properties of expanded PLLA tubes for bioresorbable stent applications

AU - Rocher, Lison

AU - Cameron, Jude

AU - Barr, Jordan

AU - Dillon, Brian

AU - Lennon, Alex B.

AU - Menary, Gary H.

PY - 2023/8/17

Y1 - 2023/8/17

N2 - Bioresorbable poly-L-lactide (PLLA) stents have the potential to fully dissolve after treating injured arteries, leaving nothing behind. However, the manufacturing process for bioresorbable stents (BRS) needs further refinement to eventually replace current permanent stents. This study investigates the effect of radial and biaxial expansion procedures on the microstructure and mechanical properties of PLLA expanded tubes using microfocus wide -angle X-ray scattering (WAXS) and multi-directional tensile tests. A complex microstructure with an orientation gradient across the thickness of the tube wall was observed and linked to the strain history experienced during processing. Correlations between the stretch ratios applied and the mechanical properties of the PLLA tubes were also noted and discussed in relation to stent application.

AB - Bioresorbable poly-L-lactide (PLLA) stents have the potential to fully dissolve after treating injured arteries, leaving nothing behind. However, the manufacturing process for bioresorbable stents (BRS) needs further refinement to eventually replace current permanent stents. This study investigates the effect of radial and biaxial expansion procedures on the microstructure and mechanical properties of PLLA expanded tubes using microfocus wide -angle X-ray scattering (WAXS) and multi-directional tensile tests. A complex microstructure with an orientation gradient across the thickness of the tube wall was observed and linked to the strain history experienced during processing. Correlations between the stretch ratios applied and the mechanical properties of the PLLA tubes were also noted and discussed in relation to stent application.

KW - biaxial expansion

KW - bioresorbable stents

KW - mechanical properties

KW - microfocus WAXS

KW - microstructure

KW - poly-L-lactide

U2 - 10.1016/j.eurpolymj.2023.112205

DO - 10.1016/j.eurpolymj.2023.112205

M3 - Article

AN - SCOPUS:85162115750

SN - 0014-3057

VL - 195

JO - European Polymer Journal

JF - European Polymer Journal

M1 - 112205

ER -

Linking processing, microstructure and mechanical properties of expanded PLLA tubes for bioresorbable stent applications

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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Student theses

Exploring the structure-processing-property relationships of Poly(l-lactic acid) in bioresorbable vascular scaffolds using high resolution characterisation

Investigating crimping and deployment of poly(L-lactic acid) bioresorbable vascular scaffolds: unravelling their impact on scaffold performance in the context of overall processing history

Investigation of the effect of nanoparticle addition and processing history on Poly(l-lactide) stent properties

Research output

Interaction of Poly L-Lactide and Tungsten Disulfide Nanotubes Studied by in Situ X-ray Scattering during Expansion of PLLA/WS2NT Nanocomposite Tubes

Cite this