Lipoprotein glycation and its metabolic consequences

T J Lyons, A J Jenkins

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Glycation of lipoproteins is implicated in the development of the macro- and microvascular complications of diabetes, atherosclerosis in general, and other disease processes including aging. Enhanced glycation may have direct effects, and may also amplify the effects of oxidative stress on lipoproteins. Most studies have examined the effects of glycation of LDL, particularly with respect to its atherogenicity. Other lipoproteins are more difficult to study because their several apolipoproteins, being of varying age, are not uniformly exposed to glucose. Inhibition of the combined stresses of glycation and oxidation towards lipoproteins may have beneficial effects on health.
Original languageEnglish
Pages (from-to)174-80
Number of pages7
JournalCurrent Opinion in Lipidology
Volume8
Issue number3
Publication statusPublished - Jun 1997

Keywords

  • Animals
  • Diabetic Angiopathies
  • Glycosylation
  • Humans
  • Lipoprotein(a)
  • Lipoproteins
  • Lipoproteins, LDL
  • Models, Biological
  • Reactive Oxygen Species

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