Localised gamma irradiation and experimental intraocular proliferation

U. Chakravarthy, T. A. Gardiner, C. J. F. Maguire, D. B. Archer

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8 Citations (Scopus)


A controlled study was undertaken to assess the effect of gamma irradiation on post-traumatic intraocular cellular proliferation. A standard perforating injury in the posterior segment of the rabbit eye was used to induce intraocular cellular proliferation and vitreo-retinal membrane formation. The site of injury was irradiated with an ophthalmic Cobalt60 applicator which provided a continuous source of gamma rays. Non-irradiated eyes developed traction retinal detachments associated with post-traumatic vitreo-retinal membranes. Irradiated eyes developed attenuated membranes or atrophic retinal scars, with the retina remaining attached. The membranes in non-irradiated eyes were highly cellular with abundant collagen, while irradiated membranes had fewer cells within a sparse collagen matrix. The episcleral fibroblasts, on autoradiographic studies appeared to be the main source of the cells that formed the proliferating tissue in both non-irradiated and irradiated eyes. In irradiated eyes both the inflammatory response and division of fibroblasts were delayed and reduced.
Original languageUndefined/Unknown
Pages (from-to)792-799
Number of pages8
JournalTransactions of the ophthalmological societies of the United Kingdom
Volume104 ( Pt 7)
Issue numberPt 7
Publication statusPublished - 1985

Bibliographical note

LR: 20061115; JID: 0200570; 50-89-5 (Thymidine); 9007-34-5 (Collagen); ppublish


  • Animals
  • Cell Division/radiation effects
  • Collagen
  • Eye/pathology/radiation effects
  • Eye Injuries/metabolism/pathology
  • Fibroblasts/radiation effects
  • Gamma Rays
  • Membranes/pathology
  • Rabbits
  • Retinal Detachment/prevention & control
  • Sclera/metabolism
  • Thymidine/metabolism
  • Time Factors
  • Wounds, Penetrating/metabolism/pathology

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