Long-term evaluation of corneal sub-basal nerve recovery after photorefractive keratectomy and influence of pars plana vitrectomy

Gian Marco Tosi*, Gianluca Martone, Tommaso Bacci, Antonio Tarantello, Stefano Baiocchi, Davide Marigliani, Gabriele Cevenini, Flavia Menicacci, Gianni Virgili, Giacomina Massaro-Giordano

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The corneal sub-basal nerve (SBN) plexus is destroyed during photorefractive keratectomy (PRK) and its recovery is still a matter of debate. In vivo confocal microscopy (IVCM) was used to evaluate SBN plexus in 23 patients at a distance of 10–25 years (mean 15.6 years) from myopic PRK. Because 8 out of the 23 PRK patients underwent pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment, IVCM was also performed on those patients 6 months after PPV. Thirteen patients matched for age and myopia served as controls (non-PRK). SBN plexus was markedly reduced after PRK compared with non-PRK eyes and showed a slow, continuous but incomplete recovery up to the end of our follow-up (range 10–25 years). PRK and non-PRK eyes showed a marked reduction in SBN density 6 months after PPV, thus demonstrating a detrimental effect exerted by PPV on SBN plexus.

Original languageEnglish
Pages (from-to)7459-7466
Number of pages8
JournalJournal of Cellular Physiology
Volume234
Issue number5
Early online date11 Nov 2018
DOIs
Publication statusPublished - May 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

  • In vivo confocal microscopy (IVCM)
  • pars plana vitrectomy (PPV)
  • photorefractive keratectomy (PRK)
  • rhegmatogenous retinal detachment (RRD)
  • sub-basal nerve (SBN) plexus

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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