Long-term evaluation of corneal sub-basal nerve recovery after photorefractive keratectomy and influence of pars plana vitrectomy

Gian Marco Tosi; Gianluca Martone; Tommaso Bacci; Antonio Tarantello; Stefano Baiocchi; Davide Marigliani; Gabriele Cevenini; Flavia Menicacci; Gianni Virgili; Giacomina Massaro-Giordano

doi:10.1002/jcp.27504

Long-term evaluation of corneal sub-basal nerve recovery after photorefractive keratectomy and influence of pars plana vitrectomy

Gian Marco Tosi^*, Gianluca Martone, Tommaso Bacci, Antonio Tarantello, Stefano Baiocchi, Davide Marigliani, Gabriele Cevenini, Flavia Menicacci, Gianni Virgili, Giacomina Massaro-Giordano

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The corneal sub-basal nerve (SBN) plexus is destroyed during photorefractive keratectomy (PRK) and its recovery is still a matter of debate. In vivo confocal microscopy (IVCM) was used to evaluate SBN plexus in 23 patients at a distance of 10–25 years (mean 15.6 years) from myopic PRK. Because 8 out of the 23 PRK patients underwent pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment, IVCM was also performed on those patients 6 months after PPV. Thirteen patients matched for age and myopia served as controls (non-PRK). SBN plexus was markedly reduced after PRK compared with non-PRK eyes and showed a slow, continuous but incomplete recovery up to the end of our follow-up (range 10–25 years). PRK and non-PRK eyes showed a marked reduction in SBN density 6 months after PPV, thus demonstrating a detrimental effect exerted by PPV on SBN plexus.

Original language	English
Pages (from-to)	7459-7466
Number of pages	8
Journal	Journal of Cellular Physiology
Volume	234
Issue number	5
Early online date	11 Nov 2018
DOIs	https://doi.org/10.1002/jcp.27504
Publication status	Published - May 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Keywords

In vivo confocal microscopy (IVCM)
pars plana vitrectomy (PPV)
photorefractive keratectomy (PRK)
rhegmatogenous retinal detachment (RRD)
sub-basal nerve (SBN) plexus

ASJC Scopus subject areas

Physiology
Clinical Biochemistry
Cell Biology

Access to Document

10.1002/jcp.27504Licence: Unspecified

Cite this

Tosi, G. M., Martone, G., Bacci, T., Tarantello, A., Baiocchi, S., Marigliani, D., Cevenini, G., Menicacci, F., Virgili, G., & Massaro-Giordano, G. (2019). Long-term evaluation of corneal sub-basal nerve recovery after photorefractive keratectomy and influence of pars plana vitrectomy. Journal of Cellular Physiology, 234(5), 7459-7466. https://doi.org/10.1002/jcp.27504

@article{0b7aa1cac237452792947499991a08d9,

title = "Long-term evaluation of corneal sub-basal nerve recovery after photorefractive keratectomy and influence of pars plana vitrectomy",

abstract = "The corneal sub-basal nerve (SBN) plexus is destroyed during photorefractive keratectomy (PRK) and its recovery is still a matter of debate. In vivo confocal microscopy (IVCM) was used to evaluate SBN plexus in 23 patients at a distance of 10–25 years (mean 15.6 years) from myopic PRK. Because 8 out of the 23 PRK patients underwent pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment, IVCM was also performed on those patients 6 months after PPV. Thirteen patients matched for age and myopia served as controls (non-PRK). SBN plexus was markedly reduced after PRK compared with non-PRK eyes and showed a slow, continuous but incomplete recovery up to the end of our follow-up (range 10–25 years). PRK and non-PRK eyes showed a marked reduction in SBN density 6 months after PPV, thus demonstrating a detrimental effect exerted by PPV on SBN plexus.",

keywords = "In vivo confocal microscopy (IVCM), pars plana vitrectomy (PPV), photorefractive keratectomy (PRK), rhegmatogenous retinal detachment (RRD), sub-basal nerve (SBN) plexus",

author = "Tosi, {Gian Marco} and Gianluca Martone and Tommaso Bacci and Antonio Tarantello and Stefano Baiocchi and Davide Marigliani and Gabriele Cevenini and Flavia Menicacci and Gianni Virgili and Giacomina Massaro-Giordano",

year = "2019",

month = may,

doi = "10.1002/jcp.27504",

language = "English",

volume = "234",

pages = "7459--7466",

journal = "Journal of Cellular Physiology",

issn = "0021-9541",

publisher = "Wiley-Liss Inc.",

number = "5",

}

Tosi, GM, Martone, G, Bacci, T, Tarantello, A, Baiocchi, S, Marigliani, D, Cevenini, G, Menicacci, F, Virgili, G & Massaro-Giordano, G 2019, 'Long-term evaluation of corneal sub-basal nerve recovery after photorefractive keratectomy and influence of pars plana vitrectomy', Journal of Cellular Physiology, vol. 234, no. 5, pp. 7459-7466. https://doi.org/10.1002/jcp.27504

TY - JOUR

T1 - Long-term evaluation of corneal sub-basal nerve recovery after photorefractive keratectomy and influence of pars plana vitrectomy

AU - Tosi, Gian Marco

AU - Martone, Gianluca

AU - Bacci, Tommaso

AU - Tarantello, Antonio

AU - Baiocchi, Stefano

AU - Marigliani, Davide

AU - Cevenini, Gabriele

AU - Menicacci, Flavia

AU - Virgili, Gianni

AU - Massaro-Giordano, Giacomina

PY - 2019/5

Y1 - 2019/5

N2 - The corneal sub-basal nerve (SBN) plexus is destroyed during photorefractive keratectomy (PRK) and its recovery is still a matter of debate. In vivo confocal microscopy (IVCM) was used to evaluate SBN plexus in 23 patients at a distance of 10–25 years (mean 15.6 years) from myopic PRK. Because 8 out of the 23 PRK patients underwent pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment, IVCM was also performed on those patients 6 months after PPV. Thirteen patients matched for age and myopia served as controls (non-PRK). SBN plexus was markedly reduced after PRK compared with non-PRK eyes and showed a slow, continuous but incomplete recovery up to the end of our follow-up (range 10–25 years). PRK and non-PRK eyes showed a marked reduction in SBN density 6 months after PPV, thus demonstrating a detrimental effect exerted by PPV on SBN plexus.

AB - The corneal sub-basal nerve (SBN) plexus is destroyed during photorefractive keratectomy (PRK) and its recovery is still a matter of debate. In vivo confocal microscopy (IVCM) was used to evaluate SBN plexus in 23 patients at a distance of 10–25 years (mean 15.6 years) from myopic PRK. Because 8 out of the 23 PRK patients underwent pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment, IVCM was also performed on those patients 6 months after PPV. Thirteen patients matched for age and myopia served as controls (non-PRK). SBN plexus was markedly reduced after PRK compared with non-PRK eyes and showed a slow, continuous but incomplete recovery up to the end of our follow-up (range 10–25 years). PRK and non-PRK eyes showed a marked reduction in SBN density 6 months after PPV, thus demonstrating a detrimental effect exerted by PPV on SBN plexus.

KW - In vivo confocal microscopy (IVCM)

KW - pars plana vitrectomy (PPV)

KW - photorefractive keratectomy (PRK)

KW - rhegmatogenous retinal detachment (RRD)

KW - sub-basal nerve (SBN) plexus

U2 - 10.1002/jcp.27504

DO - 10.1002/jcp.27504

M3 - Article

C2 - 30417371

AN - SCOPUS:85056285879

SN - 0021-9541

VL - 234

SP - 7459

EP - 7466

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

IS - 5

ER -

Long-term evaluation of corneal sub-basal nerve recovery after photorefractive keratectomy and influence of pars plana vitrectomy

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this