Long-term follow-up and “double layer sign” in patients affected by circumscribed choroidal hemangioma

Vittoria Murro, Dario Pasquale Mucciolo, Dario Giorgio*, Andrea Sodi, Maria Carla Donati, Giovanni Giacomelli, Gianni Virgili, Cinzia Mazzini, Fabrizio Giansanti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Photodynamic therapy has revolutionised the treatment of circumscribed choroidal hemangiomas. The aim of this report is to report the long-term follow-up of patients affected by circumscribed choroidal hemangioma treated using photodynamic therapy. Materials and Methods: We retrospectively reviewed patients affected by circumscribed choroidal hemangioma examined at the Retinal Medical Department at the Eye Clinic in Florence. We studied circumscribed choroidal hemangiomas treated using photodynamic therapy with at least 1 follow-up examination. Verteporfin was administered intravenously for 10 min (6 mg/m2 body surface area). After infusion (5 min), a 689 nm laser was applied with a light dose of 50 J/cm2. Results: Ten eyes of 10 patients with circumscribed choroidal hemangioma who underwent Photodynamic therapy were included in our series (2 females and 8 males; average age at diagnosis 47.8 ± 9.3 yrs.; age range: 27–56 years). Five patients (5/10; 50 %) received only the photodynamic treatment whereas 5 patients (5/10; 50 %) also received other treatments (laser photocoagulation, intravitreal injection). On average, the patients received 2 photodynamic treatments (range 1–4). Four patients (4/10, 40 %) had a > 5-year follow-up; (average 4.5 ± 3.7 yrs. range 6 months – 10 years). In 2 patients we identified the “double layer sign” at the optical coherence tomography examination on circumscribed choroidal hemangioma. Conclusions: In our series, photodynamic therapy was a safe and effective treatment for circumscribed choroidal hemangioma during long-term follow-up. The double layer sign, which can be detected in several choroidal pathologies, suggests common pathogenetic mechanisms for circumscribed choroidal hemangiomas and central serous chorioretinopathy/polypoidal choroidopathy spectrum disease.

Original languageEnglish
Article number101960
Number of pages7
JournalPhotodiagnosis and Photodynamic Therapy
Early online date17 Aug 2020
Publication statusPublished - Sept 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier B.V.

Copyright 2020 Elsevier B.V., All rights reserved.


  • Circumscribed Choroidal Hemangioma
  • Double Layer Sign
  • Hemangioma
  • Photodynamic Therapy

ASJC Scopus subject areas

  • Biophysics
  • Oncology
  • Dermatology
  • Pharmacology (medical)


Dive into the research topics of 'Long-term follow-up and “double layer sign” in patients affected by circumscribed choroidal hemangioma'. Together they form a unique fingerprint.

Cite this