Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID

Omer Elneima; John R Hurst; Carlos Echevarria; Jennifer K Quint; Samantha Walker; Salman Siddiqui; Petr Novotny; Paul E Pfeffer; Jeremy S Brown; Manu Shankar-Hari; Hamish J C McAuley; Olivia C Leavy; Aarti Shikotra; Amisha Singapuri; Marco Sereno; Matthew Richardson; Ruth M Saunders; Victoria C Harris; Linzy Houchen-Wolloff; Neil J Greening; Ewen M Harrison; Annemarie B Docherty; Nazir I Lone; James D Chalmers; Ling-Pei Ho; Alex Horsley; Michael Marks; Krisnah Poinasamy; Betty Raman; Rachael A Evans; Louise V Wain; Aziz Sheikh; Chris E Brightling; Anthony De Soyza; Liam G Heaney

doi:10.1183/23120541.00982-2023

Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID

Omer Elneima, John R Hurst, Carlos Echevarria, Jennifer K Quint, Samantha Walker, Salman Siddiqui, Petr Novotny, Paul E Pfeffer, Jeremy S Brown, Manu Shankar-Hari, Hamish J C McAuley, Olivia C Leavy, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Matthew Richardson, Ruth M Saunders, Victoria C Harris, Linzy Houchen-Wolloff, Neil J GreeningEwen M Harrison, Annemarie B Docherty, Nazir I Lone, James D Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Rachael A Evans, Louise V Wain, Aziz Sheikh, Chris E Brightling, Anthony De Soyza, Liam G Heaney

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Abstract

BackgroundThe long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown.MethodsAdult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 March 2020 and 31 March 2021 were recruited to the Post-hospitalisation COVID-19 (PHOSP-COVID) study. Participants attended research visits at 5 months and 1 year post discharge. Clinical characteristics, perceived recovery, burden of symptoms and health-related quality of life (HRQoL) of individuals with pre-existing airway disease (i.e., asthma, COPD or bronchiectasis) were compared to the non-airways group.ResultsA total of 615 out of 2697 (22.8%) participants had a history of pre-existing airway diseases (72.0% diagnosed with asthma, 22.9% COPD and 5.1% bronchiectasis). At 1 year, the airways group participants were less likely to feel fully recovered (20.4% versus 33.2%, pversus 22.0%, p=0.002), depression (31.2% versus 24.7%, p=0.006), higher percentage of impaired mobility using short physical performance battery ≤10 (57.4% versus 45.2%, pversus 16.6%, p=0.014. HRQoL assessed using EQ-5D-5L Utility Index was lower in the airways group (mean±SD 0.64±0.27 versus 0.73±0.25, pConclusionIndividuals with pre-existing airway diseases hospitalised due to COVID-19 were less likely to feel fully recovered, had lower physiological performance measurements, more burden of symptoms and reduced HRQoL up to 1 year post-hospital discharge.

Original language	English
Article number	00982-2023
Number of pages	64
Journal	ERJ Open Research
Volume	10
Issue number	4
DOIs	https://doi.org/10.1183/23120541.00982-2023
Publication status	Published - 01 Jul 2024

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Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airways diseases in the UK: a multicentre, longitudinal cohort study (PHOSP-COVID)
© 2024 The Authors. Copyright ©The authors 2024. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
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Elneima, O., Hurst, J. R., Echevarria, C., Quint, J. K., Walker, S., Siddiqui, S., Novotny, P., Pfeffer, P. E., Brown, J. S., Shankar-Hari, M., McAuley, H. J. C., Leavy, O. C., Shikotra, A., Singapuri, A., Sereno, M., Richardson, M., Saunders, R. M., Harris, V. C., Houchen-Wolloff, L., ... Heaney, L. G. (2024). Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID. ERJ Open Research, 10(4), Article 00982-2023. https://doi.org/10.1183/23120541.00982-2023

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title = "Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID",

abstract = "BackgroundThe long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown.MethodsAdult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 March 2020 and 31 March 2021 were recruited to the Post-hospitalisation COVID-19 (PHOSP-COVID) study. Participants attended research visits at 5 months and 1 year post discharge. Clinical characteristics, perceived recovery, burden of symptoms and health-related quality of life (HRQoL) of individuals with pre-existing airway disease (i.e., asthma, COPD or bronchiectasis) were compared to the non-airways group.ResultsA total of 615 out of 2697 (22.8%) participants had a history of pre-existing airway diseases (72.0% diagnosed with asthma, 22.9% COPD and 5.1% bronchiectasis). At 1 year, the airways group participants were less likely to feel fully recovered (20.4% versus 33.2%, pversus 22.0%, p=0.002), depression (31.2% versus 24.7%, p=0.006), higher percentage of impaired mobility using short physical performance battery ≤10 (57.4% versus 45.2%, pversus 16.6%, p=0.014. HRQoL assessed using EQ-5D-5L Utility Index was lower in the airways group (mean±SD 0.64±0.27 versus 0.73±0.25, pConclusionIndividuals with pre-existing airway diseases hospitalised due to COVID-19 were less likely to feel fully recovered, had lower physiological performance measurements, more burden of symptoms and reduced HRQoL up to 1 year post-hospital discharge.",

author = "Omer Elneima and Hurst, {John R} and Carlos Echevarria and Quint, {Jennifer K} and Samantha Walker and Salman Siddiqui and Petr Novotny and Pfeffer, {Paul E} and Brown, {Jeremy S} and Manu Shankar-Hari and McAuley, {Hamish J C} and Leavy, {Olivia C} and Aarti Shikotra and Amisha Singapuri and Marco Sereno and Matthew Richardson and Saunders, {Ruth M} and Harris, {Victoria C} and Linzy Houchen-Wolloff and Greening, {Neil J} and Harrison, {Ewen M} and Docherty, {Annemarie B} and Lone, {Nazir I} and Chalmers, {James D} and Ling-Pei Ho and Alex Horsley and Michael Marks and Krisnah Poinasamy and Betty Raman and Evans, {Rachael A} and Wain, {Louise V} and Aziz Sheikh and Brightling, {Chris E} and {De Soyza}, Anthony and Heaney, {Liam G}",

year = "2024",

month = jul,

day = "1",

doi = "10.1183/23120541.00982-2023",

language = "English",

volume = "10",

journal = "ERJ Open Research",

issn = "2312-0541",

publisher = "European Respiratory Society",

number = "4",

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Elneima, O, Hurst, JR, Echevarria, C, Quint, JK, Walker, S, Siddiqui, S, Novotny, P, Pfeffer, PE, Brown, JS, Shankar-Hari, M, McAuley, HJC, Leavy, OC, Shikotra, A, Singapuri, A, Sereno, M, Richardson, M, Saunders, RM, Harris, VC, Houchen-Wolloff, L, Greening, NJ, Harrison, EM, Docherty, AB, Lone, NI, Chalmers, JD, Ho, L-P, Horsley, A, Marks, M, Poinasamy, K, Raman, B, Evans, RA, Wain, LV, Sheikh, A, Brightling, CE, De Soyza, A & Heaney, LG 2024, 'Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID', ERJ Open Research, vol. 10, no. 4, 00982-2023. https://doi.org/10.1183/23120541.00982-2023

TY - JOUR

T1 - Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID

AU - Elneima, Omer

AU - Hurst, John R

AU - Echevarria, Carlos

AU - Quint, Jennifer K

AU - Walker, Samantha

AU - Siddiqui, Salman

AU - Novotny, Petr

AU - Pfeffer, Paul E

AU - Brown, Jeremy S

AU - Shankar-Hari, Manu

AU - McAuley, Hamish J C

AU - Leavy, Olivia C

AU - Shikotra, Aarti

AU - Singapuri, Amisha

AU - Sereno, Marco

AU - Richardson, Matthew

AU - Saunders, Ruth M

AU - Harris, Victoria C

AU - Houchen-Wolloff, Linzy

AU - Greening, Neil J

AU - Harrison, Ewen M

AU - Docherty, Annemarie B

AU - Lone, Nazir I

AU - Chalmers, James D

AU - Ho, Ling-Pei

AU - Horsley, Alex

AU - Marks, Michael

AU - Poinasamy, Krisnah

AU - Raman, Betty

AU - Evans, Rachael A

AU - Wain, Louise V

AU - Sheikh, Aziz

AU - Brightling, Chris E

AU - De Soyza, Anthony

AU - Heaney, Liam G

PY - 2024/7/1

Y1 - 2024/7/1

N2 - BackgroundThe long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown.MethodsAdult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 March 2020 and 31 March 2021 were recruited to the Post-hospitalisation COVID-19 (PHOSP-COVID) study. Participants attended research visits at 5 months and 1 year post discharge. Clinical characteristics, perceived recovery, burden of symptoms and health-related quality of life (HRQoL) of individuals with pre-existing airway disease (i.e., asthma, COPD or bronchiectasis) were compared to the non-airways group.ResultsA total of 615 out of 2697 (22.8%) participants had a history of pre-existing airway diseases (72.0% diagnosed with asthma, 22.9% COPD and 5.1% bronchiectasis). At 1 year, the airways group participants were less likely to feel fully recovered (20.4% versus 33.2%, pversus 22.0%, p=0.002), depression (31.2% versus 24.7%, p=0.006), higher percentage of impaired mobility using short physical performance battery ≤10 (57.4% versus 45.2%, pversus 16.6%, p=0.014. HRQoL assessed using EQ-5D-5L Utility Index was lower in the airways group (mean±SD 0.64±0.27 versus 0.73±0.25, pConclusionIndividuals with pre-existing airway diseases hospitalised due to COVID-19 were less likely to feel fully recovered, had lower physiological performance measurements, more burden of symptoms and reduced HRQoL up to 1 year post-hospital discharge.

AB - BackgroundThe long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown.MethodsAdult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 March 2020 and 31 March 2021 were recruited to the Post-hospitalisation COVID-19 (PHOSP-COVID) study. Participants attended research visits at 5 months and 1 year post discharge. Clinical characteristics, perceived recovery, burden of symptoms and health-related quality of life (HRQoL) of individuals with pre-existing airway disease (i.e., asthma, COPD or bronchiectasis) were compared to the non-airways group.ResultsA total of 615 out of 2697 (22.8%) participants had a history of pre-existing airway diseases (72.0% diagnosed with asthma, 22.9% COPD and 5.1% bronchiectasis). At 1 year, the airways group participants were less likely to feel fully recovered (20.4% versus 33.2%, pversus 22.0%, p=0.002), depression (31.2% versus 24.7%, p=0.006), higher percentage of impaired mobility using short physical performance battery ≤10 (57.4% versus 45.2%, pversus 16.6%, p=0.014. HRQoL assessed using EQ-5D-5L Utility Index was lower in the airways group (mean±SD 0.64±0.27 versus 0.73±0.25, pConclusionIndividuals with pre-existing airway diseases hospitalised due to COVID-19 were less likely to feel fully recovered, had lower physiological performance measurements, more burden of symptoms and reduced HRQoL up to 1 year post-hospital discharge.

U2 - 10.1183/23120541.00982-2023

DO - 10.1183/23120541.00982-2023

M3 - Article

SN - 2312-0541

VL - 10

JO - ERJ Open Research

JF - ERJ Open Research

IS - 4

M1 - 00982-2023

ER -

Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID

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