Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia

Andrew N Hoofnagle; Mingyuan Wu; Albina K Gosmanova; Jessica O Becker; Ellen M Wijsman; John D Brunzell; Steven E Kahn; Robert H Knopp; Timothy J Lyons; Jay W Heinecke

doi:10.1161/ATVBAHA.110.212894

Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia

Andrew N Hoofnagle, Mingyuan Wu, Albina K Gosmanova, Jessica O Becker, Ellen M Wijsman, John D Brunzell, Steven E Kahn, Robert H Knopp, Timothy J Lyons, Jay W Heinecke

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

To determine whether obesity and insulin resistance associate with changes in the protein content of high-density lipoprotein (HDL) in 2 different groups of men by using targeted proteomics.

Original language	English
Pages (from-to)	2528-34
Number of pages	7
Journal	Arteriosclerosis Thrombosis and Vascular Biology
Volume	30
Issue number	12
DOIs	https://doi.org/10.1161/ATVBAHA.110.212894
Publication status	Published - Dec 2010

Keywords

Adult
Biological Markers
Body Mass Index
Case-Control Studies
Chromatography, Liquid
Clusterin
Diabetes Mellitus, Type 2
Down-Regulation
Dyslipidemias
Humans
Indicator Dilution Techniques
Insulin Resistance
Lipoproteins, HDL
Male
Metabolic Syndrome X
Middle Aged
Obesity
Oklahoma
Proteomics
Reproducibility of Results
Tandem Mass Spectrometry
Triglycerides
Washington

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/ATVBAHA.110.212894

Cite this

Hoofnagle, A. N., Wu, M., Gosmanova, A. K., Becker, J. O., Wijsman, E. M., Brunzell, J. D., Kahn, S. E., Knopp, R. H., Lyons, T. J., & Heinecke, J. W. (2010). Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia. Arteriosclerosis Thrombosis and Vascular Biology, 30(12), 2528-34. https://doi.org/10.1161/ATVBAHA.110.212894

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abstract = "To determine whether obesity and insulin resistance associate with changes in the protein content of high-density lipoprotein (HDL) in 2 different groups of men by using targeted proteomics.",

keywords = "Adult, Biological Markers, Body Mass Index, Case-Control Studies, Chromatography, Liquid, Clusterin, Diabetes Mellitus, Type 2, Down-Regulation, Dyslipidemias, Humans, Indicator Dilution Techniques, Insulin Resistance, Lipoproteins, HDL, Male, Metabolic Syndrome X, Middle Aged, Obesity, Oklahoma, Proteomics, Reproducibility of Results, Tandem Mass Spectrometry, Triglycerides, Washington",

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doi = "10.1161/ATVBAHA.110.212894",

language = "English",

volume = "30",

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journal = "Arteriosclerosis Thrombosis and Vascular Biology",

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AU - Hoofnagle, Andrew N

AU - Wu, Mingyuan

AU - Gosmanova, Albina K

AU - Becker, Jessica O

AU - Wijsman, Ellen M

AU - Brunzell, John D

AU - Kahn, Steven E

AU - Knopp, Robert H

AU - Lyons, Timothy J

AU - Heinecke, Jay W

PY - 2010/12

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N2 - To determine whether obesity and insulin resistance associate with changes in the protein content of high-density lipoprotein (HDL) in 2 different groups of men by using targeted proteomics.

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KW - Biological Markers

KW - Body Mass Index

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KW - Chromatography, Liquid

KW - Clusterin

KW - Diabetes Mellitus, Type 2

KW - Down-Regulation

KW - Dyslipidemias

KW - Humans

KW - Indicator Dilution Techniques

KW - Insulin Resistance

KW - Lipoproteins, HDL

KW - Male

KW - Metabolic Syndrome X

KW - Middle Aged

KW - Obesity

KW - Oklahoma

KW - Proteomics

KW - Reproducibility of Results

KW - Tandem Mass Spectrometry

KW - Triglycerides

KW - Washington

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SN - 1079-5642

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JO - Arteriosclerosis Thrombosis and Vascular Biology

JF - Arteriosclerosis Thrombosis and Vascular Biology

IS - 12

ER -

Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia

Abstract

Keywords

UN SDGs

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