Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia

Andrew N Hoofnagle, Mingyuan Wu, Albina K Gosmanova, Jessica O Becker, Ellen M Wijsman, John D Brunzell, Steven E Kahn, Robert H Knopp, Timothy J Lyons, Jay W Heinecke

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

To determine whether obesity and insulin resistance associate with changes in the protein content of high-density lipoprotein (HDL) in 2 different groups of men by using targeted proteomics.
Original languageEnglish
Pages (from-to)2528-34
Number of pages7
JournalArteriosclerosis Thrombosis and Vascular Biology
Volume30
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Adult
  • Biological Markers
  • Body Mass Index
  • Case-Control Studies
  • Chromatography, Liquid
  • Clusterin
  • Diabetes Mellitus, Type 2
  • Down-Regulation
  • Dyslipidemias
  • Humans
  • Indicator Dilution Techniques
  • Insulin Resistance
  • Lipoproteins, HDL
  • Male
  • Metabolic Syndrome X
  • Middle Aged
  • Obesity
  • Oklahoma
  • Proteomics
  • Reproducibility of Results
  • Tandem Mass Spectrometry
  • Triglycerides
  • Washington

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