Low dose effects of ionizing radiation on normal tissue stem cells

Katrin Manda*, Joy N. Kavanagh, Dajana Buttler, Kevin M. Prise, Guido Hildebrandt

*Corresponding author for this work

Research output: Contribution to journalLiterature review

17 Citations (Scopus)
598 Downloads (Pure)

Abstract

In recent years, there has been growing evidence for the involvement of stem cells in cancer initiation. As a result of their long life span, stem cells may have an increased propensity to accumulate genetic damage relative to differentiated cells. Therefore, stem cells of normal tissues may be important targets for radiation-induced carcinogenesis.

Knowledge of the effects of ionizing radiation (IR) on normal stem cells and on the processes involved in carcinogenesis is very limited. The influence of high doses of IR (>5 Gy) on proliferation, cell cycle and induction of senescence has been demonstrated in stem cells. There have been limited studies of the effects of moderate (0.5–5 Gy) and low doses (<0.5 Gy) of IR on stem cells however, the effect of low dose IR (LD-IR) on normal stem cells as possible targets for radiation-induced carcinogenesis has not been studied in any depth. There may also be important parallels between stem cell responses and those of cancer stem cells, which may highlight potential key common mechanisms of their response and radiosensitivity.

This review will provide an overview of the current knowledge of radiation-induced effects on normal stem cells, with particular focus on low and moderate doses of IR.

Original languageEnglish
Pages (from-to)6-14
Number of pages9
JournalMutation research/Reviews in Mutation Research
Volume761
Early online date22 Feb 2014
DOIs
Publication statusPublished - Jul 2014

Keywords

  • Normal stem cells
  • Irradiation
  • Low dose
  • Carcinogenesis
  • INDUCED GENOMIC INSTABILITY
  • DOUBLE-STRAND BREAKS
  • BONE-MARROW INJURY
  • HEMATOPOIETIC STEM
  • NITRIC-OXIDE
  • IN-VITRO
  • HOMOLOGOUS RECOMBINATION
  • MESENCHYMAL TRANSITION
  • CANCER PROGRESSION
  • HUMAN FIBROBLASTS

Cite this

Manda, Katrin ; Kavanagh, Joy N. ; Buttler, Dajana ; Prise, Kevin M. ; Hildebrandt, Guido. / Low dose effects of ionizing radiation on normal tissue stem cells. In: Mutation research/Reviews in Mutation Research. 2014 ; Vol. 761. pp. 6-14.
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Low dose effects of ionizing radiation on normal tissue stem cells. / Manda, Katrin; Kavanagh, Joy N.; Buttler, Dajana; Prise, Kevin M.; Hildebrandt, Guido.

In: Mutation research/Reviews in Mutation Research, Vol. 761, 07.2014, p. 6-14.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Low dose effects of ionizing radiation on normal tissue stem cells

AU - Manda, Katrin

AU - Kavanagh, Joy N.

AU - Buttler, Dajana

AU - Prise, Kevin M.

AU - Hildebrandt, Guido

PY - 2014/7

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N2 - In recent years, there has been growing evidence for the involvement of stem cells in cancer initiation. As a result of their long life span, stem cells may have an increased propensity to accumulate genetic damage relative to differentiated cells. Therefore, stem cells of normal tissues may be important targets for radiation-induced carcinogenesis.Knowledge of the effects of ionizing radiation (IR) on normal stem cells and on the processes involved in carcinogenesis is very limited. The influence of high doses of IR (>5 Gy) on proliferation, cell cycle and induction of senescence has been demonstrated in stem cells. There have been limited studies of the effects of moderate (0.5–5 Gy) and low doses (<0.5 Gy) of IR on stem cells however, the effect of low dose IR (LD-IR) on normal stem cells as possible targets for radiation-induced carcinogenesis has not been studied in any depth. There may also be important parallels between stem cell responses and those of cancer stem cells, which may highlight potential key common mechanisms of their response and radiosensitivity.This review will provide an overview of the current knowledge of radiation-induced effects on normal stem cells, with particular focus on low and moderate doses of IR.

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