Low frequency of the TEL/AML1 fusion gene in acute lymphoblastic leukaemia in Spain.

R. García-Sanz, I. Alaejos, A. Orfão, A. Rasillo, M.C. Chillón, M.D. Tabernero, M.V. Mateos, R. López-Pérez, D. González, A. Balanzategui, M. González, J.F. San Miguel, A. Bortolucci

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39 Citations (Scopus)

Abstract

We report on a series of Spanish patients with acute lymphoblastic leukaemia in whom the t(12;21) [TEL/AML1] translocation could not be identified with two sensitive techniques: reverse transcript-polymerase chain reaction (RT-PCR) and fluorescence in-situ hybridization (FISH). 101 cases were analysed: 38 children (29 B-cell precursor; nine T-cell precursor) and 63 adults (48 B-cell precursor; 15 T-cell precursor). Specific RT-PCR to amplify the TEL/AML1 fusion transcript was negative in all 101 cases. Moreover, all 38 paediatric samples were also negative by interphase FISH analysis for the presence of the TEL/AML1 fusion. These results suggest the existence of geographic/race variations in the genotype of acute lymphoblastic leukaemia (ALL).
Original languageEnglish
Pages (from-to)667-669
Number of pages3
JournalBritish Journal of Haematology
Volume107
Issue number3
Publication statusPublished - Dec 1999

Keywords

  • Adolescent
  • Adult
  • Child
  • Chromosomes, Human, Pair 12
  • Chromosomes, Human, Pair 21
  • Core Binding Factor Alpha 2 Subunit
  • Female
  • Gene Frequency
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Neoplasm Proteins
  • Oncogene Proteins, Fusion
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Reverse Transcriptase Polymerase Chain Reaction
  • Spain
  • Translocation, Genetic

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