Low molecular weight measles immunoglobulin M in subacute sclerosing panencephalitis and acute measles

J H Connolly; D M Simpson; A Trudgett; A P Hopkins

Low molecular weight measles immunoglobulin M in subacute sclerosing panencephalitis and acute measles

J H Connolly, D M Simpson, A Trudgett, A P Hopkins

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Thirty eight patients with subacute sclerosing panencephalitis (SSPE) were investigated. Five patients who previously had measles immunoglobulin M (IgM) detected in unfractionated serum and cerebrospinal fluid (CSF) had measles IgM exclusively in the low molecular weight (LMW) fractions of serum and CSF. Measles IgM had previously not been found in unfractionated serum from 33 patients but was detected exclusively in the LMW fractions of serum from 30 patients. Seven children with acute measles had the expected high molecular weight (HMW) measles IgM in serum but 5 also had LMW measles IgM. Four young adults who had had measles in childhood had neither HMW nor LMW measles IgM in their sera.

Original language	English
Pages (from-to)	407-10
Number of pages	4
Journal	Postgraduate Medical Journal
Volume	61
Issue number	715
Publication status	Published - May 1985

Keywords

Acute Disease
Adult
Child
Female
Humans
Immunoglobulin M
Measles
Molecular Weight
Pregnancy
Subacute Sclerosing Panencephalitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{aa5c3efc9a5f4eceb9b68b5ad6bc8439,

title = "Low molecular weight measles immunoglobulin M in subacute sclerosing panencephalitis and acute measles",

abstract = "Thirty eight patients with subacute sclerosing panencephalitis (SSPE) were investigated. Five patients who previously had measles immunoglobulin M (IgM) detected in unfractionated serum and cerebrospinal fluid (CSF) had measles IgM exclusively in the low molecular weight (LMW) fractions of serum and CSF. Measles IgM had previously not been found in unfractionated serum from 33 patients but was detected exclusively in the LMW fractions of serum from 30 patients. Seven children with acute measles had the expected high molecular weight (HMW) measles IgM in serum but 5 also had LMW measles IgM. Four young adults who had had measles in childhood had neither HMW nor LMW measles IgM in their sera.",

keywords = "Acute Disease, Adult, Child, Female, Humans, Immunoglobulin M, Measles, Molecular Weight, Pregnancy, Subacute Sclerosing Panencephalitis",

author = "Connolly, {J H} and Simpson, {D M} and A Trudgett and Hopkins, {A P}",

year = "1985",

month = may,

language = "English",

volume = "61",

pages = "407--10",

journal = "Postgraduate Medical Journal",

issn = "0032-5473",

publisher = "BMJ Publishing Group",

number = "715",

}

TY - JOUR

T1 - Low molecular weight measles immunoglobulin M in subacute sclerosing panencephalitis and acute measles

AU - Connolly, J H

AU - Simpson, D M

AU - Trudgett, A

AU - Hopkins, A P

PY - 1985/5

Y1 - 1985/5

N2 - Thirty eight patients with subacute sclerosing panencephalitis (SSPE) were investigated. Five patients who previously had measles immunoglobulin M (IgM) detected in unfractionated serum and cerebrospinal fluid (CSF) had measles IgM exclusively in the low molecular weight (LMW) fractions of serum and CSF. Measles IgM had previously not been found in unfractionated serum from 33 patients but was detected exclusively in the LMW fractions of serum from 30 patients. Seven children with acute measles had the expected high molecular weight (HMW) measles IgM in serum but 5 also had LMW measles IgM. Four young adults who had had measles in childhood had neither HMW nor LMW measles IgM in their sera.

AB - Thirty eight patients with subacute sclerosing panencephalitis (SSPE) were investigated. Five patients who previously had measles immunoglobulin M (IgM) detected in unfractionated serum and cerebrospinal fluid (CSF) had measles IgM exclusively in the low molecular weight (LMW) fractions of serum and CSF. Measles IgM had previously not been found in unfractionated serum from 33 patients but was detected exclusively in the LMW fractions of serum from 30 patients. Seven children with acute measles had the expected high molecular weight (HMW) measles IgM in serum but 5 also had LMW measles IgM. Four young adults who had had measles in childhood had neither HMW nor LMW measles IgM in their sera.

KW - Acute Disease

KW - Adult

KW - Child

KW - Female

KW - Humans

KW - Immunoglobulin M

KW - Measles

KW - Molecular Weight

KW - Pregnancy

KW - Subacute Sclerosing Panencephalitis

M3 - Article

C2 - 4022875

VL - 61

SP - 407

EP - 410

JO - Postgraduate Medical Journal

JF - Postgraduate Medical Journal

SN - 0032-5473

IS - 715

ER -

Low molecular weight measles immunoglobulin M in subacute sclerosing panencephalitis and acute measles

Abstract

Keywords

UN SDGs

Fingerprint

Cite this