Low molecular weight measles immunoglobulin M in subacute sclerosing panencephalitis and acute measles

J H Connolly, D M Simpson, A Trudgett, A P Hopkins

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Thirty eight patients with subacute sclerosing panencephalitis (SSPE) were investigated. Five patients who previously had measles immunoglobulin M (IgM) detected in unfractionated serum and cerebrospinal fluid (CSF) had measles IgM exclusively in the low molecular weight (LMW) fractions of serum and CSF. Measles IgM had previously not been found in unfractionated serum from 33 patients but was detected exclusively in the LMW fractions of serum from 30 patients. Seven children with acute measles had the expected high molecular weight (HMW) measles IgM in serum but 5 also had LMW measles IgM. Four young adults who had had measles in childhood had neither HMW nor LMW measles IgM in their sera.
Original languageEnglish
Pages (from-to)407-10
Number of pages4
JournalPostgraduate Medical Journal
Volume61
Issue number715
Publication statusPublished - May 1985

Keywords

  • Acute Disease
  • Adult
  • Child
  • Female
  • Humans
  • Immunoglobulin M
  • Measles
  • Molecular Weight
  • Pregnancy
  • Subacute Sclerosing Panencephalitis

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