LRP-1 variation is not associated with risk of Alzheimer's disease

Katy A Chalmers; Rachel Barker; Peter A Passmore; Francesco Panza; Davide Seripa; Vincenzo Solfrizzi; Seth Love; Jonathan A Prince; Patrick G Kehoe

LRP-1 variation is not associated with risk of Alzheimer's disease

Katy A Chalmers, Rachel Barker, Peter A Passmore, Francesco Panza, Davide Seripa, Vincenzo Solfrizzi, Seth Love, Jonathan A Prince, Patrick G Kehoe

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9 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is characterised by the extensive deposition of amyloid beta (Aß) within the parenchyma and vasculature of the brain. It is hypothesised that a dysfunction in Aß degradation and/or its removal from the brain may result in accumulation as plaques. Low density lipoprotein receptor-related protein-1 (LRP-1) is a multifunctional receptor shown to be involved in cholesterol metabolism but also the removal of Aß from the brain. Its ability to transport Aß from the brain to the periphery has made it an attractive candidate for involvement in Alzheimer's disease (AD). We have assessed the frequencies of 9 tag- SNPs and the commonly studied synonymous SNP within exon 3 (rs1799986) in a multi-centre AD/control cohort and performed haplotype analysis. We found no evidence from a combined total of 412 controls and 1057 AD patients to support the involvement of LRP-1 variation, including the most commonly studied variant in rs1799986 in conferring genetic susceptibility to increased risk of AD.

Original language	English
Pages (from-to)	104-13
Number of pages	10
Journal	International journal of molecular epidemiology and genetics
Volume	1
Issue number	2
Publication status	Published - 2010

Cite this

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title = "LRP-1 variation is not associated with risk of Alzheimer's disease",

abstract = "Alzheimer's disease (AD) is characterised by the extensive deposition of amyloid beta (A{\ss}) within the parenchyma and vasculature of the brain. It is hypothesised that a dysfunction in A{\ss} degradation and/or its removal from the brain may result in accumulation as plaques. Low density lipoprotein receptor-related protein-1 (LRP-1) is a multifunctional receptor shown to be involved in cholesterol metabolism but also the removal of A{\ss} from the brain. Its ability to transport A{\ss} from the brain to the periphery has made it an attractive candidate for involvement in Alzheimer's disease (AD). We have assessed the frequencies of 9 tag- SNPs and the commonly studied synonymous SNP within exon 3 (rs1799986) in a multi-centre AD/control cohort and performed haplotype analysis. We found no evidence from a combined total of 412 controls and 1057 AD patients to support the involvement of LRP-1 variation, including the most commonly studied variant in rs1799986 in conferring genetic susceptibility to increased risk of AD.",

author = "Chalmers, {Katy A} and Rachel Barker and Passmore, {Peter A} and Francesco Panza and Davide Seripa and Vincenzo Solfrizzi and Seth Love and Prince, {Jonathan A} and Kehoe, {Patrick G}",

year = "2010",

language = "English",

volume = "1",

pages = "104--13",

journal = "International journal of molecular epidemiology and genetics",

issn = "1948-1756",

publisher = "e-Century Publishing Corporation",

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TY - JOUR

T1 - LRP-1 variation is not associated with risk of Alzheimer's disease

AU - Chalmers, Katy A

AU - Barker, Rachel

AU - Passmore, Peter A

AU - Panza, Francesco

AU - Seripa, Davide

AU - Solfrizzi, Vincenzo

AU - Love, Seth

AU - Prince, Jonathan A

AU - Kehoe, Patrick G

PY - 2010

Y1 - 2010

N2 - Alzheimer's disease (AD) is characterised by the extensive deposition of amyloid beta (Aß) within the parenchyma and vasculature of the brain. It is hypothesised that a dysfunction in Aß degradation and/or its removal from the brain may result in accumulation as plaques. Low density lipoprotein receptor-related protein-1 (LRP-1) is a multifunctional receptor shown to be involved in cholesterol metabolism but also the removal of Aß from the brain. Its ability to transport Aß from the brain to the periphery has made it an attractive candidate for involvement in Alzheimer's disease (AD). We have assessed the frequencies of 9 tag- SNPs and the commonly studied synonymous SNP within exon 3 (rs1799986) in a multi-centre AD/control cohort and performed haplotype analysis. We found no evidence from a combined total of 412 controls and 1057 AD patients to support the involvement of LRP-1 variation, including the most commonly studied variant in rs1799986 in conferring genetic susceptibility to increased risk of AD.

AB - Alzheimer's disease (AD) is characterised by the extensive deposition of amyloid beta (Aß) within the parenchyma and vasculature of the brain. It is hypothesised that a dysfunction in Aß degradation and/or its removal from the brain may result in accumulation as plaques. Low density lipoprotein receptor-related protein-1 (LRP-1) is a multifunctional receptor shown to be involved in cholesterol metabolism but also the removal of Aß from the brain. Its ability to transport Aß from the brain to the periphery has made it an attractive candidate for involvement in Alzheimer's disease (AD). We have assessed the frequencies of 9 tag- SNPs and the commonly studied synonymous SNP within exon 3 (rs1799986) in a multi-centre AD/control cohort and performed haplotype analysis. We found no evidence from a combined total of 412 controls and 1057 AD patients to support the involvement of LRP-1 variation, including the most commonly studied variant in rs1799986 in conferring genetic susceptibility to increased risk of AD.

M3 - Article

C2 - 21537384

SN - 1948-1756

VL - 1

SP - 104

EP - 113

JO - International journal of molecular epidemiology and genetics

JF - International journal of molecular epidemiology and genetics

IS - 2

ER -

LRP-1 variation is not associated with risk of Alzheimer's disease

Abstract

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