Lyotropic liquid crystals for parenteral drug delivery

Vivek P. Chavda; Shilpa Dawre; Anjali Pandya; Lalitkumar K. Vora; Dharti H. Modh; Vidhi Shah; Divyang J. Dave; Vandana Patravale

doi:10.1016/j.jconrel.2022.06.062

Lyotropic liquid crystals for parenteral drug delivery

Vivek P. Chavda^*, Shilpa Dawre, Anjali Pandya, Lalitkumar K. Vora, Dharti H. Modh, Vidhi Shah, Divyang J. Dave, Vandana Patravale

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

36 Citations (Scopus)

700 Downloads (Pure)

Abstract

The necessity for long-term treatments of chronic diseases has encouraged the development of novel long-acting parenteral formulations intending to improve drug pharmacokinetics and therapeutic efficacy. Lately, one of the novel approaches has been developed based on lipid-based liquid crystals. The lyotropic liquid crystal (LLC) systems consist of amphiphilic molecules and are formed in presence of solvents with the most common types being cubic, hexagonal and lamellar mesophases. LC injectables have been recently developed based on polar lipids that spontaneously form liquid crystal nanoparticles in aqueous tissue environments to create the in-situ long-acting sustained-release depot to provide treatment efficacy over extended periods. In this manuscript, we have consolidated and summarized the various type of liquid crystals, recent formulation advancements, analytical evaluation, and therapeutic application of lyotropic liquid crystals in the field of parenteral sustained release drug delivery.

Original language	English
Pages (from-to)	533-549
Number of pages	17
Journal	Journal of Controlled Release
Volume	349
Early online date	20 Jul 2022
DOIs	https://doi.org/10.1016/j.jconrel.2022.06.062
Publication status	Published - Sept 2022

Bibliographical note

Funding Information:
V.P.C. wants to dedicate this work to L M College of pharmacy as a part of the 75th year celebration of the college. V.P.C. is grateful to the L.M. College of Pharmacy, Ahmedabad, India, for providing necessary support in carrying out the literature search.

Publisher Copyright:
© 2022 The Authors

Keywords

Drug delivery
In situ phase transition
Liquid crystals
Lyotropic liquid crystals
Microemulsion
Parenteral delivery
Surfactant

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/j.jconrel.2022.06.062Licence: CC BY

Lyotropic liquid crystals for parenteral drug delivery
Copyright 2022 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited
Final published version, 2.61 MBLicence: CC BY

Cite this

@article{66c5992bc0ee4af585d47aaa54f6492b,

title = "Lyotropic liquid crystals for parenteral drug delivery",

abstract = "The necessity for long-term treatments of chronic diseases has encouraged the development of novel long-acting parenteral formulations intending to improve drug pharmacokinetics and therapeutic efficacy. Lately, one of the novel approaches has been developed based on lipid-based liquid crystals. The lyotropic liquid crystal (LLC) systems consist of amphiphilic molecules and are formed in presence of solvents with the most common types being cubic, hexagonal and lamellar mesophases. LC injectables have been recently developed based on polar lipids that spontaneously form liquid crystal nanoparticles in aqueous tissue environments to create the in-situ long-acting sustained-release depot to provide treatment efficacy over extended periods. In this manuscript, we have consolidated and summarized the various type of liquid crystals, recent formulation advancements, analytical evaluation, and therapeutic application of lyotropic liquid crystals in the field of parenteral sustained release drug delivery.",

keywords = "Drug delivery, In situ phase transition, Liquid crystals, Lyotropic liquid crystals, Microemulsion, Parenteral delivery, Surfactant",

author = "Chavda, {Vivek P.} and Shilpa Dawre and Anjali Pandya and Vora, {Lalitkumar K.} and Modh, {Dharti H.} and Vidhi Shah and Dave, {Divyang J.} and Vandana Patravale",

note = "Funding Information: V.P.C. wants to dedicate this work to L M College of pharmacy as a part of the 75th year celebration of the college. V.P.C. is grateful to the L.M. College of Pharmacy, Ahmedabad, India, for providing necessary support in carrying out the literature search. Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = sep,

doi = "10.1016/j.jconrel.2022.06.062",

language = "English",

volume = "349",

pages = "533--549",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Lyotropic liquid crystals for parenteral drug delivery

AU - Chavda, Vivek P.

AU - Dawre, Shilpa

AU - Pandya, Anjali

AU - Vora, Lalitkumar K.

AU - Modh, Dharti H.

AU - Shah, Vidhi

AU - Dave, Divyang J.

AU - Patravale, Vandana

N1 - Funding Information: V.P.C. wants to dedicate this work to L M College of pharmacy as a part of the 75th year celebration of the college. V.P.C. is grateful to the L.M. College of Pharmacy, Ahmedabad, India, for providing necessary support in carrying out the literature search. Publisher Copyright: © 2022 The Authors

PY - 2022/9

Y1 - 2022/9

N2 - The necessity for long-term treatments of chronic diseases has encouraged the development of novel long-acting parenteral formulations intending to improve drug pharmacokinetics and therapeutic efficacy. Lately, one of the novel approaches has been developed based on lipid-based liquid crystals. The lyotropic liquid crystal (LLC) systems consist of amphiphilic molecules and are formed in presence of solvents with the most common types being cubic, hexagonal and lamellar mesophases. LC injectables have been recently developed based on polar lipids that spontaneously form liquid crystal nanoparticles in aqueous tissue environments to create the in-situ long-acting sustained-release depot to provide treatment efficacy over extended periods. In this manuscript, we have consolidated and summarized the various type of liquid crystals, recent formulation advancements, analytical evaluation, and therapeutic application of lyotropic liquid crystals in the field of parenteral sustained release drug delivery.

AB - The necessity for long-term treatments of chronic diseases has encouraged the development of novel long-acting parenteral formulations intending to improve drug pharmacokinetics and therapeutic efficacy. Lately, one of the novel approaches has been developed based on lipid-based liquid crystals. The lyotropic liquid crystal (LLC) systems consist of amphiphilic molecules and are formed in presence of solvents with the most common types being cubic, hexagonal and lamellar mesophases. LC injectables have been recently developed based on polar lipids that spontaneously form liquid crystal nanoparticles in aqueous tissue environments to create the in-situ long-acting sustained-release depot to provide treatment efficacy over extended periods. In this manuscript, we have consolidated and summarized the various type of liquid crystals, recent formulation advancements, analytical evaluation, and therapeutic application of lyotropic liquid crystals in the field of parenteral sustained release drug delivery.

KW - Drug delivery

KW - In situ phase transition

KW - Liquid crystals

KW - Lyotropic liquid crystals

KW - Microemulsion

KW - Parenteral delivery

KW - Surfactant

U2 - 10.1016/j.jconrel.2022.06.062

DO - 10.1016/j.jconrel.2022.06.062

M3 - Review article

C2 - 35792188

AN - SCOPUS:85134711415

SN - 0168-3659

VL - 349

SP - 533

EP - 549

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Lyotropic liquid crystals for parenteral drug delivery

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this