Lyotropic liquid crystals for parenteral drug delivery

Vivek P. Chavda*, Shilpa Dawre, Anjali Pandya, Lalitkumar K. Vora, Dharti H. Modh, Vidhi Shah, Divyang J. Dave, Vandana Patravale

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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The necessity for long-term treatments of chronic diseases has encouraged the development of novel long-acting parenteral formulations intending to improve drug pharmacokinetics and therapeutic efficacy. Lately, one of the novel approaches has been developed based on lipid-based liquid crystals. The lyotropic liquid crystal (LLC) systems consist of amphiphilic molecules and are formed in presence of solvents with the most common types being cubic, hexagonal and lamellar mesophases. LC injectables have been recently developed based on polar lipids that spontaneously form liquid crystal nanoparticles in aqueous tissue environments to create the in-situ long-acting sustained-release depot to provide treatment efficacy over extended periods. In this manuscript, we have consolidated and summarized the various type of liquid crystals, recent formulation advancements, analytical evaluation, and therapeutic application of lyotropic liquid crystals in the field of parenteral sustained release drug delivery.

Original languageEnglish
Pages (from-to)533-549
Number of pages17
JournalJournal of Controlled Release
Early online date20 Jul 2022
Publication statusPublished - Sep 2022

Bibliographical note

Funding Information:
V.P.C. wants to dedicate this work to L M College of pharmacy as a part of the 75th year celebration of the college. V.P.C. is grateful to the L.M. College of Pharmacy, Ahmedabad, India, for providing necessary support in carrying out the literature search.

Publisher Copyright:
© 2022 The Authors


  • Drug delivery
  • In situ phase transition
  • Liquid crystals
  • Lyotropic liquid crystals
  • Microemulsion
  • Parenteral delivery
  • Surfactant

ASJC Scopus subject areas

  • Pharmaceutical Science


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