Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls

Neele S. Dellschaft; Christabella Ng; Caroline Hoad; Luca Marciani; Robin Spiller; Iain Stewart; Alex Menys; Helen Barr; Penny A. Gowland; Giles Major; Alan R. Smyth

doi:10.1016/j.jcf.2021.12.007

Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls

Neele S. Dellschaft, Christabella Ng, Caroline Hoad, Luca Marciani, Robin Spiller, Iain Stewart, Alex Menys, Helen Barr, Penny A. Gowland, Giles Major, Alan R. Smyth^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

People with cystic fibrosis (CF) experience digestive symptoms but the mechanisms are incompletely understood. Here we explore causes and consequences of slower gastrointestinal transit using magnetic resonance imaging (MRI). Twelve people with CF and 12 healthy controls, matched for age and gender, underwent MRI scans, both fasted and after standardised meals, over 6.5 h. Fasted small bowel motility scores were lower in CF than in controls. No difference in ascending colon chyme T₁ was detected. The difference in texture between small bowel and colon contents, seen in health, was diminished in CF. The ascending colon in CF participants had an abnormal appearance compared to controls. MRI offers unique potential to evaluate gut luminal content, colonic mucosa and intestinal motor activity. These new data support the theoretical cycle of desiccation, dysmotility and delayed transit as a cause of gastrointestinal symptoms in CF.

Original language	English
Pages (from-to)	502-505
Number of pages	4
Journal	Journal of Cystic Fibrosis
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/j.jcf.2021.12.007
Publication status	Published - 28 May 2022
Externally published	Yes

Bibliographical note

Funding Information:
ND, CH, LM, HB, IS & PG have nothing to disclose. CN and GM report grants and speaker honorarium from Vertex, outside the submitted work. RS reports grants from Zespri International Ltd and Sanofi- Aventis, as well as lecturing fees from Menarini and Alfawasserman, outside the submitted work. AM is the CEO of Motilent Limited, a medical imaging analysis company. AS reports grants from Vertex, as well as speaker honoraria and expenses from Teva and Vertex, outside the submitted work. In addition, AS has a patent issued “Alkyl quinolones as biomarkers of Pseudomonas aeruginosa infection and uses thereof”.

Funding Information:
Funding for the Gut Imaging for Function and Transit in CF (GIFT-CF) study was received from the Cystic Fibrosis Foundation (Clinical Pilot and Feasibility Award SMYTH18A0-I ), the Cystic Fibrosis Trust ( VIA 061 ), and the National Institute for Health Research Nottingham Biomedical Research Centre . The views expressed are those of the authors and not necessarily those of the National Health Service (NHS) , the NIHR , or the Department of Health and Social Care .

Funding Information:
Funding for the Gut Imaging for Function and Transit in CF (GIFT-CF) study was received from the Cystic Fibrosis Foundation (Clinical Pilot and Feasibility Award SMYTH18A0-I), the Cystic Fibrosis Trust (VIA 061), and the National Institute for Health Research Nottingham Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the National Health Service (NHS), the NIHR, or the Department of Health and Social Care.

Publisher Copyright:
© 2021 European Cystic Fibrosis Society

Keywords

Cystic fibrosis
Gastrointestinal tract
Magnetic resonance imaging

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

Access to Document

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Cite this

Dellschaft, N. S., Ng, C., Hoad, C., Marciani, L., Spiller, R., Stewart, I., Menys, A., Barr, H., Gowland, P. A., Major, G., & Smyth, A. R. (2022). Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls. Journal of Cystic Fibrosis, 21(3), 502-505. https://doi.org/10.1016/j.jcf.2021.12.007

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title = "Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls",

abstract = "People with cystic fibrosis (CF) experience digestive symptoms but the mechanisms are incompletely understood. Here we explore causes and consequences of slower gastrointestinal transit using magnetic resonance imaging (MRI). Twelve people with CF and 12 healthy controls, matched for age and gender, underwent MRI scans, both fasted and after standardised meals, over 6.5 h. Fasted small bowel motility scores were lower in CF than in controls. No difference in ascending colon chyme T1 was detected. The difference in texture between small bowel and colon contents, seen in health, was diminished in CF. The ascending colon in CF participants had an abnormal appearance compared to controls. MRI offers unique potential to evaluate gut luminal content, colonic mucosa and intestinal motor activity. These new data support the theoretical cycle of desiccation, dysmotility and delayed transit as a cause of gastrointestinal symptoms in CF.",

keywords = "Cystic fibrosis, Gastrointestinal tract, Magnetic resonance imaging",

author = "Dellschaft, {Neele S.} and Christabella Ng and Caroline Hoad and Luca Marciani and Robin Spiller and Iain Stewart and Alex Menys and Helen Barr and Gowland, {Penny A.} and Giles Major and Smyth, {Alan R.}",

note = "Funding Information: ND, CH, LM, HB, IS & PG have nothing to disclose. CN and GM report grants and speaker honorarium from Vertex, outside the submitted work. RS reports grants from Zespri International Ltd and Sanofi- Aventis, as well as lecturing fees from Menarini and Alfawasserman, outside the submitted work. AM is the CEO of Motilent Limited, a medical imaging analysis company. AS reports grants from Vertex, as well as speaker honoraria and expenses from Teva and Vertex, outside the submitted work. In addition, AS has a patent issued “Alkyl quinolones as biomarkers of Pseudomonas aeruginosa infection and uses thereof”. Funding Information: Funding for the Gut Imaging for Function and Transit in CF (GIFT-CF) study was received from the Cystic Fibrosis Foundation (Clinical Pilot and Feasibility Award SMYTH18A0-I ), the Cystic Fibrosis Trust ( VIA 061 ), and the National Institute for Health Research Nottingham Biomedical Research Centre . The views expressed are those of the authors and not necessarily those of the National Health Service (NHS) , the NIHR , or the Department of Health and Social Care . Funding Information: Funding for the Gut Imaging for Function and Transit in CF (GIFT-CF) study was received from the Cystic Fibrosis Foundation (Clinical Pilot and Feasibility Award SMYTH18A0-I), the Cystic Fibrosis Trust (VIA 061), and the National Institute for Health Research Nottingham Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the National Health Service (NHS), the NIHR, or the Department of Health and Social Care. Publisher Copyright: {\textcopyright} 2021 European Cystic Fibrosis Society",

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doi = "10.1016/j.jcf.2021.12.007",

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Dellschaft, NS, Ng, C, Hoad, C, Marciani, L, Spiller, R, Stewart, I, Menys, A, Barr, H, Gowland, PA, Major, G & Smyth, AR 2022, 'Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls', Journal of Cystic Fibrosis, vol. 21, no. 3, pp. 502-505. https://doi.org/10.1016/j.jcf.2021.12.007

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T1 - Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls

AU - Dellschaft, Neele S.

AU - Ng, Christabella

AU - Hoad, Caroline

AU - Marciani, Luca

AU - Spiller, Robin

AU - Stewart, Iain

AU - Menys, Alex

AU - Barr, Helen

AU - Gowland, Penny A.

AU - Major, Giles

AU - Smyth, Alan R.

N1 - Funding Information: ND, CH, LM, HB, IS & PG have nothing to disclose. CN and GM report grants and speaker honorarium from Vertex, outside the submitted work. RS reports grants from Zespri International Ltd and Sanofi- Aventis, as well as lecturing fees from Menarini and Alfawasserman, outside the submitted work. AM is the CEO of Motilent Limited, a medical imaging analysis company. AS reports grants from Vertex, as well as speaker honoraria and expenses from Teva and Vertex, outside the submitted work. In addition, AS has a patent issued “Alkyl quinolones as biomarkers of Pseudomonas aeruginosa infection and uses thereof”. Funding Information: Funding for the Gut Imaging for Function and Transit in CF (GIFT-CF) study was received from the Cystic Fibrosis Foundation (Clinical Pilot and Feasibility Award SMYTH18A0-I ), the Cystic Fibrosis Trust ( VIA 061 ), and the National Institute for Health Research Nottingham Biomedical Research Centre . The views expressed are those of the authors and not necessarily those of the National Health Service (NHS) , the NIHR , or the Department of Health and Social Care . Funding Information: Funding for the Gut Imaging for Function and Transit in CF (GIFT-CF) study was received from the Cystic Fibrosis Foundation (Clinical Pilot and Feasibility Award SMYTH18A0-I), the Cystic Fibrosis Trust (VIA 061), and the National Institute for Health Research Nottingham Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the National Health Service (NHS), the NIHR, or the Department of Health and Social Care. Publisher Copyright: © 2021 European Cystic Fibrosis Society

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Y1 - 2022/5/28

N2 - People with cystic fibrosis (CF) experience digestive symptoms but the mechanisms are incompletely understood. Here we explore causes and consequences of slower gastrointestinal transit using magnetic resonance imaging (MRI). Twelve people with CF and 12 healthy controls, matched for age and gender, underwent MRI scans, both fasted and after standardised meals, over 6.5 h. Fasted small bowel motility scores were lower in CF than in controls. No difference in ascending colon chyme T1 was detected. The difference in texture between small bowel and colon contents, seen in health, was diminished in CF. The ascending colon in CF participants had an abnormal appearance compared to controls. MRI offers unique potential to evaluate gut luminal content, colonic mucosa and intestinal motor activity. These new data support the theoretical cycle of desiccation, dysmotility and delayed transit as a cause of gastrointestinal symptoms in CF.

AB - People with cystic fibrosis (CF) experience digestive symptoms but the mechanisms are incompletely understood. Here we explore causes and consequences of slower gastrointestinal transit using magnetic resonance imaging (MRI). Twelve people with CF and 12 healthy controls, matched for age and gender, underwent MRI scans, both fasted and after standardised meals, over 6.5 h. Fasted small bowel motility scores were lower in CF than in controls. No difference in ascending colon chyme T1 was detected. The difference in texture between small bowel and colon contents, seen in health, was diminished in CF. The ascending colon in CF participants had an abnormal appearance compared to controls. MRI offers unique potential to evaluate gut luminal content, colonic mucosa and intestinal motor activity. These new data support the theoretical cycle of desiccation, dysmotility and delayed transit as a cause of gastrointestinal symptoms in CF.

KW - Cystic fibrosis

KW - Gastrointestinal tract

KW - Magnetic resonance imaging

U2 - 10.1016/j.jcf.2021.12.007

DO - 10.1016/j.jcf.2021.12.007

M3 - Article

C2 - 34922853

AN - SCOPUS:85121786455

SN - 1569-1993

VL - 21

SP - 502

EP - 505

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

IS - 3

ER -

Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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