Malignant glaucoma treated by low-dose laser cycloplasty: a 1-year multicenter prospective non-comparative study

Hai-Shuang Lin, Xiao-Ping Xu, Xuan-Li Zheng, Ji-Bing Wang, Su-Jie Fan, Zuo-Hong Wu, Su-Mian Cheng, Li-Jun Zhao, Qin-Hua Cai, Shao-Dan Zhang, Shan-Shan Liu, Ai-Guo Lyu, Ying Zhang, Hong Chen, Dan-Ni Jiang, Wu-Liang Li, Nathan Congdon, Clement C. Tham, Ming-Guang He, Yuan-Bo LiangMalignant Glaucoma Treatment Trial Study (MGTT) Group

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Abstract

Aim: To report a one-year clinical outcomes of low-dose laser cycloplasty (LCP) among malignant glaucoma patients. METHODS: In this prospective, multicenter, non-comparative clinical study, participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in China. Patients were followed up at 1wk, 1, 3, 6, and 12mo. Intraocular pressure (IOP), number of glaucoma medications, anterior chamber depth (ACD), and complications were recorded. Anatomical success was defined as the reformation of the anterior chamber based on slit-lamp biomicroscopy. Recurrence was defined by the presence of a shallow or flat anterior chamber after initial recovery from treatment.

Results: A total of 34 eyes received LCP. Mean IOP and medications decreased from 36.1±11.5 mm Hg with 3.3±1.5 glaucoma medications pre-treatment to 20.9±9.8 mm Hg (P<0.001) with 2.9±1.6 medications (P=0.046) at 1d, and 17.4±6.7 mm Hg (P<0.001) with 1.3±1.7 medications (P<0.001) at 12mo. The ACD increased from 1.1±0.8 mm at baseline to 1.7±1.0 mm and to 2.0±0.5 mm at 1d and 12mo, respectively. A total of 32 (94.1%) eyes achieved initial anatomical success. During follow-up, 2 (5.9%) eyes failed and 8 (23.5%) eyes relapsed, yielding a 12-month anatomical success rate of 64.3%. Complications including anterior synechia (8.82%), choroidal/ciliary detachment (5.88%) and hypopyon (2.94%) were observed within 1wk.

Conclusion: LCP is simple, safe, and effective in reforming the anterior chamber in malignant glaucoma.

Original languageEnglish
Pages (from-to)1248-1254
JournalInternational Journal of Ophthalmology
Volume17
Issue number7
Early online date25 Jun 2024
DOIs
Publication statusPublished - 18 Jul 2024

Keywords

  • intraocular pressure
  • low-dose laser cycloplasty
  • anatomical success
  • anterior chamber reformation
  • malignant glaucoma

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