Malignant pleural mesothelioma: current treatments and emerging drugs

C. Belli, Dean Fennell, M. Giovannini, G. Gaudino, L. Mutti

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Malignant pleural mesothelioma (MPM) is an uncommon disease whose incidence is increasing worldwide over the past 30 years. Surgical resection and radiotherapy represent the standard treatment in patient with resectable MPM. Chemotherapy is also necessary to reduce incidence of distant metastases, but the optimal setting of treatment (neoadjuvant, adjuvant and intrapleural) is not clarified. For the patients with unresectable MPM, the combination cisplatin and pemetrexed or ralitrexed is the standard treatment as supported by a Phase III study. Better understanding of molecular pathways involved in MPM has enabled inclusion of new drugs targeted against pathways responsible for proliferation, cell survival and angiogenesis. Objective: This review discusses the current treatment option, the specific signal pathways activated in MPM and the novel agents under evaluation in clinical trials. Methods: We use for this article abstracts, papers, oral presentations from ASCO and the website http://www.clinical-trials.gov. Results/conclusion: This review summarizes the activity of chemotherapy and of new agents under evaluation in clinical trials. The better understanding of molecular pathways activated in MPM will hopefully provide new therapeutic options for these patients in the future.
Original languageEnglish
Pages (from-to)423-437
Number of pages15
JournalExpert opinion on emerging drugs
Volume14
Issue number3
DOIs
Publication statusPublished - Sep 2009

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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