Abstract
Second-generation carnosine analogs bearing the histidyl-hydrazide moiety have been synthesized and tested for their efficiency in scavenging malondialdehyde (MDA) derived from lipid peroxidation and for their ability to reverse the glycation process in the glucose-ethylamine Schiff base model. The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress.
Original language | English |
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Pages (from-to) | 6158-6163 |
Number of pages | 6 |
Journal | Bioorganic & Medicinal Chemistry |
Volume | 15(18) |
Issue number | 18 |
DOIs | |
Publication status | Published - 15 Sept 2007 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science