Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs.

Andrea Guiotto, P. Ruzza, M.A. Babizhayev, A. Calderan

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Second-generation carnosine analogs bearing the histidyl-hydrazide moiety have been synthesized and tested for their efficiency in scavenging malondialdehyde (MDA) derived from lipid peroxidation and for their ability to reverse the glycation process in the glucose-ethylamine Schiff base model. The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress.
Original languageEnglish
Pages (from-to)6158-6163
Number of pages6
JournalBioorganic & Medicinal Chemistry
Volume15(18)
Issue number18
DOIs
Publication statusPublished - 15 Sep 2007

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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