Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs.

Andrea Guiotto; P. Ruzza; M.A. Babizhayev; A. Calderan

doi:10.1016/j.bmc.2007.06.029

Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs.

Andrea Guiotto
, P. Ruzza
, M.A. Babizhayev
, A. Calderan

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Second-generation carnosine analogs bearing the histidyl-hydrazide moiety have been synthesized and tested for their efficiency in scavenging malondialdehyde (MDA) derived from lipid peroxidation and for their ability to reverse the glycation process in the glucose-ethylamine Schiff base model. The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress.

Original language	English
Pages (from-to)	6158-6163
Number of pages	6
Journal	Bioorganic & Medicinal Chemistry
Volume	15(18)
Issue number	18
DOIs	https://doi.org/10.1016/j.bmc.2007.06.029
Publication status	Published - 15 Sept 2007

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

Access to Document

10.1016/j.bmc.2007.06.029

Cite this

@article{61c5ef8787b841369f8c350ee7ebb761,

title = "Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs.",

abstract = "Second-generation carnosine analogs bearing the histidyl-hydrazide moiety have been synthesized and tested for their efficiency in scavenging malondialdehyde (MDA) derived from lipid peroxidation and for their ability to reverse the glycation process in the glucose-ethylamine Schiff base model. The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress.",

author = "Andrea Guiotto and P. Ruzza and M.A. Babizhayev and A. Calderan",

year = "2007",

month = sep,

day = "15",

doi = "10.1016/j.bmc.2007.06.029",

language = "English",

volume = "15(18)",

pages = "6158--6163",

journal = "Bioorganic \& Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Ltd",

number = "18",

}

TY - JOUR

T1 - Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs.

AU - Guiotto, Andrea

AU - Ruzza, P.

AU - Babizhayev, M.A.

AU - Calderan, A.

PY - 2007/9/15

Y1 - 2007/9/15

N2 - Second-generation carnosine analogs bearing the histidyl-hydrazide moiety have been synthesized and tested for their efficiency in scavenging malondialdehyde (MDA) derived from lipid peroxidation and for their ability to reverse the glycation process in the glucose-ethylamine Schiff base model. The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress.

AB - Second-generation carnosine analogs bearing the histidyl-hydrazide moiety have been synthesized and tested for their efficiency in scavenging malondialdehyde (MDA) derived from lipid peroxidation and for their ability to reverse the glycation process in the glucose-ethylamine Schiff base model. The data obtained indicate that this class of compounds maintains the activity profile of carnosine and is a suitable candidate for the treatment of disorders caused by oxidative stress.

UR - https://www.scopus.com/pages/publications/34447637790

U2 - 10.1016/j.bmc.2007.06.029

DO - 10.1016/j.bmc.2007.06.029

M3 - Article

C2 - 17604632

SN - 0968-0896

VL - 15(18)

SP - 6158

EP - 6163

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

IS - 18

ER -

Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs.

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this