Manipulation of Autophagy by Bacterial Pathogens Impacts Host Immunity

Tobias C. Kunz, Flavia Viana, Carmen Buchrieser, Pedro Escoll

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

utophagy is a highly conserved catabolic process, degrading unnecessary or damaged components in the eukaryotic cell to maintain cellular homeostasis, but it is also an intrinsic cellular defence mechanism to remove invading pathogens. A crosstalk between autophagy and innate or adaptive immune responses has been recently reported, whereby autophagy influences both, innate and adaptive immunity like the production and secretion of pro-inflammatory cytokines or MHC class II antigen presentation to T cells. Pathogenic bacteria have evolved diverse strategies to manipulate autophagy, mechanisms that also impact host immune responses at different levels. Here we discuss the influence of autophagy on self-autonomous, innate and adaptive immunity and then focus on how bacterial mechanisms that shape autophagy may impact the host immune system.
Original languageEnglish
Pages (from-to)81-98
JournalCurrent Issues in Molecular Biology
Volume25
DOIs
Publication statusPublished - 01 Jan 2018

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