Manual versus target-controlled infusions of propofol

D.S. Breslin, Rajinder Mirakhur, J.E. Reid, A. Kyle

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Summary Target-controlled infusion systems have been shown to result in the administration of larger doses of propofol, which may result in delayed emergence and recovery from anaesthesia. The aim of this study was to investigate if this was due to a difference in the depth of hypnosis (using the bispectral index monitoring) between the manual and target controlled systems of administration. Fifty unpremedicated patients undergoing elective surgery were randomly allocated to have their anaesthesia maintained with manual or target-controlled propofol infusion schemes. In both groups, the rate of propofol administration was adjusted according to the standard clinical criteria while bispectral index scores were recorded by an observer not involved in the delivery of anaesthesia. The total dose of propofol used was higher in the target controlled group (mean 9.9 [standard deviation 1.6] compared with 8.1 [1.0] in the manual group [p
Original languageEnglish
Pages (from-to)1059-1063
Number of pages5
Issue number11
Publication statusPublished - Nov 2004

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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