Manufacturing & characterisation of lipid nanoparticles by microfluidics

Eman Jaradat, Edward Weaver, Adam Meziane, Dimitrios Lamprou*

*Corresponding author for this work

Research output: Contribution to conferencePosterpeer-review

Abstract

Applying nanoparticles (NPs) technology for therapeutic purposes, particularly for targeting delivery as Drug Delivery System (DDS), makes a significant development in the drug administration systems for a number of medicinal purposes, including overcoming the limitations of chemotherapy. Between the different platforms of NPs, lipid-based NPs (e.g., liposomes) reported as the less toxic formulation in vivo, beside the ability to carry hydrophobic or hydrophilic molecules, and the prolonged halflife. Among the multiple methods of preparing liposomes, microfluidic technology is a novel method for the manufacturing of liposomes. Microfluidics offering a high-level control of the process's various parameters, which support controlling particle size, distribution, and physiochemical properties. Using microfluidic technology to encapsulate hydrophobic drugs (e.g., cancer drugs), has shown a better uptake and potency in several cell lines in comparison to other carriers prepared by non-microfluidic methods.
Original languageEnglish
Publication statusAccepted - 01 Sep 2021
Event2021 UKICRS Virtual Symposium -
Duration: 13 Oct 202113 Oct 2021
https://www.ukicrs.org/2021-virtual-symposium.html

Conference

Conference2021 UKICRS Virtual Symposium
Period13/10/202113/10/2021
Internet address

Keywords

  • Microfluidics
  • Drug Delivery
  • Liposomes
  • cancer therapeutics
  • nanomedicines

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