Manufacturing & characterisation of lipid nanoparticles by microfluidics

Applying nanoparticles (NPs) technology for therapeutic purposes, particularly for targeting delivery as Drug Delivery System (DDS), makes a significant development in the drug administration systems for a number of medicinal purposes, including overcoming the limitations of chemotherapy. Between the different platforms of NPs, lipid-based NPs (e.g., liposomes) reported as the less toxic formulation in vivo, beside the ability to carry hydrophobic or hydrophilic molecules, and the prolonged halflife. Among the multiple methods of preparing liposomes, microfluidic technology is a novel method for the manufacturing of liposomes. Microfluidics offering a high-level control of the process's various parameters, which support controlling particle size, distribution, and physiochemical properties. Using microfluidic technology to encapsulate hydrophobic drugs (e.g., cancer drugs), has shown a better uptake and potency in several cell lines in comparison to other carriers prepared by non-microfluidic methods.