Marine Collagen Reinforcement of Calcium Phosphate Bone Cements: A Biological Assessment

Iwan, Gareth Palmer, John Nelson, Wolfgang Schatton, Nicholas Dunne, Fraser Buchanan, Susan Clarke

Research output: Contribution to conferenceAbstractpeer-review


Induction of in vivo responses by implanted biomaterials is of great interest in the medical device field. Calcium phosphate bone cements (CPCs) can potentially promote natural bone remodelling and ingrowth in vivo and, as such are becoming more common place in a range of orthopaedic procedures. However, concerns remain regarding their mechanical and handling properties. Compressive modulus and fracture toughness of CPCs can be improved, without compromising injectability and setting time, through the incorporation of bovine collagen fibres1. Incorporation of marine derived collagen fibres has also yielded similar improvements2. It is hypothesised that, due to its role in bone formation and function, that incorporation of collagen in CPCs will also result in biological benefits.
The biological properties of α-TCP-CPC were largely unchanged by the incorporation of marine derived collagen. However, as a result of significant improvements to the mechanical properties, its incorporation may still result in a suitable alternative to some commercially available bone cements.
Original languageEnglish
Publication statusPublished - 01 Sep 2015
Event27th European Conference on Biomaterials ESB2015 - Poland, Kraków, Poland
Duration: 30 Aug 201503 Sep 2015


Conference27th European Conference on Biomaterials ESB2015


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