Marker-to-marker linkage disequilibrium on chromosomes 5q, 6p, and 8p in Irish high-density schizophrenia pedigrees

K S Kendler, C J MacLean, Y Ma, F A O'Neill, D Walsh, R E Straub

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33 Citations (Scopus)

Abstract

Linkage disequilibrium (LD) is a potentially powerful tool for the localization of disease genes for complex disorders. Most prior studies of the relationship between genetic distance and LD have examined only very short distances, focusing on the role of LD in fine-mapping and positional cloning. We examine here the relationship between marker-to-marker (M-M) LD and somewhat greater genetic distances. We analyzed 622 M-M pairings on chromosomes 6p, 8p, and 5q in 265 native Irish pedigrees ascertained for a high density of schizophrenia. LD, significant at the 5% level, was found for 96% of all M-M pairings within 0.5 cM, for 67% within 0.5-1 cM, for 35% within 1-2 cM, for 15% within 2-4 cM, for 8% within 5-10 cM, and for 7% above 10 cM. Thus, in Irish families selected for a high density of schizophrenia, M-M LD may be very common within 0.5 cM and frequent up to distances of 2 cM.
Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume88
Issue number1
Publication statusPublished - 05 Feb 1999

Keywords

  • Chromosomes, Human, Pair 5
  • Chromosomes, Human, Pair 6
  • Chromosomes, Human, Pair 8
  • Genetic Markers
  • Haplotypes
  • Humans
  • Ireland
  • Linkage Disequilibrium
  • Microsatellite Repeats
  • Models, Statistical
  • Pedigree
  • Schizophrenia

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