Marrow aplasia developing 13 years after HLA-identical sibling allogeneic transplantation for chronic myeloid leukaemia: successful treatment with antithymocyte globulin and peripheral blood stem cell infusion from the original donor

D O'Donghaile, P J Hayden, S L McCarron, E M Doyle, M Lawler, P V Browne, E Conneally, E Vandenberghe, S R McCann, Mark Lawler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Secondary or late graft failure has been defined as the development of inadequate marrow function after initial engraftment has been achieved. We describe a case of profound marrow aplasia occurring 13 years after sibling allogeneic bone marrow transplantation for chronic myeloid leukaemia (CML) in first chronic phase. Although the patient remained a complete donor chimera, thereby suggesting that an unselected infusion of donor peripheral blood stem cells (PBSC) or bone marrow might be indicated, the newly acquired aplasia was thought to be immune in aetiology and some immunosuppression was therefore considered appropriate. Rapid haematological recovery was achieved after the infusion of unselected PBSC from the original donor following conditioning with anti-thymocyte globulin (ATG).

Original languageEnglish
Pages (from-to)258-60
Number of pages3
JournalEuropean Journal of Haematology
Volume76
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Antilymphocyte Serum
  • Bone Marrow Diseases
  • Bone Marrow Transplantation
  • Female
  • Histocompatibility Testing
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Middle Aged
  • Peripheral Blood Stem Cell Transplantation
  • Siblings
  • Transplantation, Homologous
  • Treatment Outcome

Fingerprint Dive into the research topics of 'Marrow aplasia developing 13 years after HLA-identical sibling allogeneic transplantation for chronic myeloid leukaemia: successful treatment with antithymocyte globulin and peripheral blood stem cell infusion from the original donor'. Together they form a unique fingerprint.

Cite this