Mass-manufacturable scintillation-based optical fiber dosimeters for brachytherapy

Agnieszka Gierej, Tigran Baghdasaryan, Michael Martyn, Peter Woulfe, Owen Mc Laughlin, Kevin Prise, Geraldine Workman, Sinead O'Keeffe, Kurt Rochlitz, Sergey Verlinski, Agnese Giaz, Romualdo Santoro, Massimo Caccia, Francis Berghmans, Jürgen Van Erps*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Scintillation-based fiber dosimeters are a powerful tool for minimally invasive localized real-time monitoring of the dose rate during Low Dose Rate (LDR) and High Dose Rate (HDR) brachytherapy (BT). This paper presents the design, fabrication, and characterization of such dosimeters, consisting of scintillating sensor tips attached to polymer optical fiber (POF). The sensor tips consist of inorganic scintillators, i.e. Gd2O2S:Tb for LDR-BT, and Y2O3:Eu+4YVO4:Eu for HDR-BT, dispersed in a polymer host. The shape and size of the tips are optimized using non-sequential ray tracing simulations towards maximizing the collection and coupling of the scintillation signal into the POF. They are then manufactured by means of a custom moulding process implemented on a commercial hot embossing machine, paving the way towards series production. Dosimetry experiments in water phantoms show that both the HDR-BT and LDR-BT sensors feature good consistency in the magnitude of the average photon count rate and that the photon count rate signal is not significantly affected by variations in sensor tip composition and geometry. Whilst individual calibration remains necessary, the proposed dosimeters show great potential for in-vivo dosimetry for brachytherapy.

Original languageEnglish
Article number116237
JournalBiosensors and Bioelectronics
Volume255
Early online date26 Mar 2024
DOIs
Publication statusEarly online date - 26 Mar 2024

Publications and Copyright Policy

This work is licensed under Queen’s Research Publications and Copyright Policy.

Keywords

  • Brachytherapy
  • Compression moulding
  • Inorganic scintillators
  • Optical fiber
  • Radiation sensor

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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