TY - JOUR
T1 - Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the Pregnancy And Childhood Epigenetics Consortium
AU - Ronkainen, Justiina
AU - Heiskala, Anni
AU - Vehmeijer, Florianne O.L.
AU - Lowry, Estelle
AU - Caramaschi, Doretta
AU - Estrada Gutiérrez, Guadalupe
AU - Heiss, Jonathan A.
AU - Hummel, Nadine
AU - Keikkala, Elina
AU - Kvist, Tuomas
AU - Kupsco, Allison
AU - Melton, Phillip E.
AU - Pesce, Giancarlo
AU - Soomro, Munawar H.
AU - Vives-Usano, Marta
AU - Baiz, Nour
AU - Binder, Elisabeth
AU - Czamara, Darina
AU - Guxens, Mònica
AU - Mustaniemi, Sanna
AU - London, Stephanie J.
AU - Rauschert, Sebastian
AU - Vääräsmäki, Marja
AU - Vrijheid, Martine
AU - Ziegler, Anette-G.
AU - Annesi-Maesano, Isabella
AU - Bustamante, Mariona
AU - Huang, Rae-Chi
AU - Hummel, Sandra
AU - Just, Allan C.
AU - Kajantie, Eero
AU - Lahti, Jari
AU - Lawlor, Deborah
AU - Räikkönen, Katri
AU - Järvelin, Marjo-Riitta
AU - Felix, Janine F
AU - Sebert, Sylvain
PY - 2020/12/17
Y1 - 2020/12/17
N2 - Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences. To test this in humans, we meta-analysed the epigenome-wide associations of maternal haemoglobin levels during pregnancy with offspring DNA methylation in 3,967 newborn cord blood and 1,534 child and 1,962 adolescent whole-blood samples derived from ten cohorts. DNA methylation was measured using Illumina Infinium Methylation450K or MethylationEPIC arrays covering 450,000 and 850,000 methylation sites, respectively. There was no statistical support for association of maternal haemoglobin levels with offspring DNA methylation either at individual methylation sites or clustered in regions. For most participants, maternal haemoglobin levels were within the normal range in the current study, whereas adverse perinatal outcomes often arise at the extremes. Thus, this study does not rule out the possibility that associations with offspring DNA methylation might be seen in studies with more extreme maternal haemoglobin levels.
AB - Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences. To test this in humans, we meta-analysed the epigenome-wide associations of maternal haemoglobin levels during pregnancy with offspring DNA methylation in 3,967 newborn cord blood and 1,534 child and 1,962 adolescent whole-blood samples derived from ten cohorts. DNA methylation was measured using Illumina Infinium Methylation450K or MethylationEPIC arrays covering 450,000 and 850,000 methylation sites, respectively. There was no statistical support for association of maternal haemoglobin levels with offspring DNA methylation either at individual methylation sites or clustered in regions. For most participants, maternal haemoglobin levels were within the normal range in the current study, whereas adverse perinatal outcomes often arise at the extremes. Thus, this study does not rule out the possibility that associations with offspring DNA methylation might be seen in studies with more extreme maternal haemoglobin levels.
U2 - 10.1080/15592294.2020.1864171
DO - 10.1080/15592294.2020.1864171
M3 - Article
SN - 1559-2294
JO - Epigenetics
JF - Epigenetics
ER -