Maternal lipids at 28 weeks gestation and offspring adiposity at age 5-7 years

Parag K. Thaware, Sonia McKenna, Christopher C. Patterson, Claire Casey, David R. McCance

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1 Citation (Scopus)
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Context- Obesity is a global epidemic, and there is a focus on identifying markers of obesity in children with a view to prevention. 
Objective- We aimed to prospectively examine the association of maternal fasting lipids with adiposity in 5-7-year old offspring in a large observational study.
Design- 1612 pregnant women were recruited to the Belfast centre of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study in a large tertiary maternity hospital at an average of 28 weeks gestation. Maternal fasting total cholesterol, LDL-cholesterol (LDL-C), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) were estimated at 28 weeks gestation. At follow-up (5-7 years later), 1224 offspring were re-examined and adiposity expressed as body mass index (BMI) Z score (1990 British Growth Standard) and sum of skin fold thicknesses (triceps, subscapular and suprailiac). Statistical significance was more rigorously defined as p<0.01 to allow for multiple comparisons.
Results- No linear relation was found between maternal lipids and offspring BMI Z score or sum of skin folds (p≥0.01) using correlation analysis. Using logistic regression, there was no relation between maternal lipids and offspring adiposity controlled for birthweight Z score, offspring age, offspring gender, smoking during pregnancy, maternal BMI during pregnancy and fasting glucose during pregnancy, (p≥0.01), although the association between maternal LDL cholesterol and offspring BMI Z score ≥85th percentile approached significance [OR 1.15 (1.03 to 1.29) p=0.02].
Conclusion-Maternal 28 week gestational fasting lipids are not associated with offspring BMI or subcutaneous adiposity at age 5-7 years.
Original languageEnglish
Pages (from-to)3767–3772
JournalThe Journal of Clinical Endocrinology & Metabolism
Issue number10
Early online date17 Jul 2018
Publication statusPublished - 01 Oct 2018


  • Pregnancy
  • HAPO
  • lipid metabolism
  • anthropometry


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