Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite

Jorge M. Santos; Neuza Duarte; Jessica Kehrer; Jai Ramesar; M. Cristina Avramut; Abraham J.  Koster; Johannes T.  Dessens; Friedrich Frischknecht; Séverine Chevalley-Maurel; Chris J.  Janse; Blandine Franke-Fayard; Gunnar R Mair

doi:10.1073/pnas.1522381113

Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite

Jorge M. Santos, Neuza Duarte, Jessica Kehrer, Jai Ramesar, M. Cristina Avramut, Abraham J. Koster, Johannes T. Dessens, Friedrich Frischknecht, Séverine Chevalley-Maurel, Chris J. Janse, Blandine Franke-Fayard, Gunnar R Mair

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Transmission of the malaria parasite from the mammalian host to the mosquito vector requires the formation of adequately adapted parasite forms and stage-specific organelles. Here we show that formation of the crystalloid—a unique and short-lived organelle of the Plasmodium ookinete and oocyst stage required for sporogony—is dependent on the precisely timed expression of the S-acyl-transferase DHHC10. DHHC10, translationally repressed in female Plasmodium berghei gametocytes, is activated translationally during ookinete formation, where the protein is essential for the formation of the crystalloid, the correct targeting of crystalloid-resident protein LAP2, and malaria parasite transmission.

Original language	English
Pages (from-to)	7183-7188
Journal	Proceedings of the National Academy of Sciences
Volume	113
Issue number	26
DOIs	https://doi.org/10.1073/pnas.1522381113
Publication status	Published - 28 Jun 2016
Externally published	Yes

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Santos, J. M., Duarte, N., Kehrer, J., Ramesar, J., Avramut, M. C., Koster, A. J., Dessens, J. T., Frischknecht, F., Chevalley-Maurel, S., Janse, C. J., Franke-Fayard, B., & Mair, G. R. (2016). Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite. Proceedings of the National Academy of Sciences, 113 (26), 7183-7188. https://doi.org/10.1073/pnas.1522381113

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title = "Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite",

abstract = "Transmission of the malaria parasite from the mammalian host to the mosquito vector requires the formation of adequately adapted parasite forms and stage-specific organelles. Here we show that formation of the crystalloid—a unique and short-lived organelle of the Plasmodium ookinete and oocyst stage required for sporogony—is dependent on the precisely timed expression of the S-acyl-transferase DHHC10. DHHC10, translationally repressed in female Plasmodium berghei gametocytes, is activated translationally during ookinete formation, where the protein is essential for the formation of the crystalloid, the correct targeting of crystalloid-resident protein LAP2, and malaria parasite transmission.",

author = "Santos, {Jorge M.} and Neuza Duarte and Jessica Kehrer and Jai Ramesar and Avramut, {M. Cristina} and Koster, {Abraham J.} and Dessens, {Johannes T.} and Friedrich Frischknecht and S{\'e}verine Chevalley-Maurel and Janse, {Chris J.} and Blandine Franke-Fayard and Mair, {Gunnar R}",

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doi = "10.1073/pnas.1522381113",

language = "English",

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Santos, JM, Duarte, N, Kehrer, J, Ramesar, J, Avramut, MC, Koster, AJ, Dessens, JT, Frischknecht, F, Chevalley-Maurel, S, Janse, CJ, Franke-Fayard, B & Mair, GR 2016, 'Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite', Proceedings of the National Academy of Sciences, vol. 113 , no. 26, pp. 7183-7188. https://doi.org/10.1073/pnas.1522381113

TY - JOUR

T1 - Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite

AU - Santos, Jorge M.

AU - Duarte, Neuza

AU - Kehrer, Jessica

AU - Ramesar, Jai

AU - Avramut, M. Cristina

AU - Koster, Abraham J.

AU - Dessens, Johannes T.

AU - Frischknecht, Friedrich

AU - Chevalley-Maurel, Séverine

AU - Janse, Chris J.

AU - Franke-Fayard, Blandine

AU - Mair, Gunnar R

PY - 2016/6/28

Y1 - 2016/6/28

N2 - Transmission of the malaria parasite from the mammalian host to the mosquito vector requires the formation of adequately adapted parasite forms and stage-specific organelles. Here we show that formation of the crystalloid—a unique and short-lived organelle of the Plasmodium ookinete and oocyst stage required for sporogony—is dependent on the precisely timed expression of the S-acyl-transferase DHHC10. DHHC10, translationally repressed in female Plasmodium berghei gametocytes, is activated translationally during ookinete formation, where the protein is essential for the formation of the crystalloid, the correct targeting of crystalloid-resident protein LAP2, and malaria parasite transmission.

AB - Transmission of the malaria parasite from the mammalian host to the mosquito vector requires the formation of adequately adapted parasite forms and stage-specific organelles. Here we show that formation of the crystalloid—a unique and short-lived organelle of the Plasmodium ookinete and oocyst stage required for sporogony—is dependent on the precisely timed expression of the S-acyl-transferase DHHC10. DHHC10, translationally repressed in female Plasmodium berghei gametocytes, is activated translationally during ookinete formation, where the protein is essential for the formation of the crystalloid, the correct targeting of crystalloid-resident protein LAP2, and malaria parasite transmission.

U2 - 10.1073/pnas.1522381113

DO - 10.1073/pnas.1522381113

M3 - Article

C2 - 27303037

SN - 0027-8424

VL - 113

SP - 7183

EP - 7188

JO - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

IS - 26

ER -

Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite

Abstract

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