Measurement of nasal patency in anesthetized and conscious dogs

Michael C Koss, Yongxin Yu, John A Hey, Robbie L McLeod

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Experiments were undertaken to characterize a noninvasive chronic, model of nasal congestion in which nasal patency is measured using acoustic rhinometry. Compound 48/80 was administered intranasally to elicit nasal congestion in five beagle dogs either by syringe (0.5 ml) in thiopental sodium-anesthetized animals or as a mist (0.25 ml) in the same animals in the conscious state. Effects of mast cell degranulation on nasal cavity volume as well as on minimal cross-sectional area (A(min)) and intranasal distance to A(min) (D(min)) were studied. Compound 48/80 caused a dose-related decrease in nasal cavity volume and A(min) together with a variable increase in D(min). Maximal responses were seen at 90-120 min. Compound 48/80 was less effective in producing nasal congestion in conscious animals, which also had significantly larger basal nasal cavity volumes. These results demonstrate the utility of using acoustic rhinometry to measure parameters of nasal patency in dogs and suggest that this model may prove useful in studies of the actions of decongestant drugs.
Original languageEnglish
Pages (from-to)617-21
Number of pages5
JournalJournal of applied physiology (Bethesda, Md. : 1985)
Volume92
Issue number2
DOIs
Publication statusPublished - Feb 2002

Keywords

  • Anesthesia
  • Animals
  • Dogs
  • Dose-Response Relationship, Drug
  • Male
  • Nasal Cavity
  • Nasal Obstruction
  • Pulmonary Ventilation
  • Reference Values
  • Rhinometry, Acoustic
  • Time Factors
  • p-Methoxy-N-methylphenethylamine

Fingerprint Dive into the research topics of 'Measurement of nasal patency in anesthetized and conscious dogs'. Together they form a unique fingerprint.

  • Cite this