Measures of body habitus are associated with lung function in adults with cystic fibrosis: A population-based study

Doug L. Forrester, Alan J. Knox, Alan R. Smyth, Andrew W. Fogarty*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
8 Downloads (Pure)

Abstract

Background: Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung function in CF. 

Methods: Cross-sectional study design using UK CF registry data from 2096 clinically stable adults. 

Results: Serum creatinine and BMI were positively and independently associated with FEV1 and FVC. One standard deviation increment in serum creatinine was associated with an FEV1 increase of 171ml (95% confidence intervals CI: +116 to +227ml) in males and 90ml (95% CI: +46 to +133ml) in females. Compared to the reference group of 20-24.9kg/m2, those with a BMI<20kg/m2 had lower FEV1 with values of -642ml (95%CI: -784 to -500ml) for males and -468ml (95%CI: -564 to -372ml) for females. 

Conclusions: Prospective studies and controlled trials are required to ascertain if these associations have therapeutic potential in modifying disease progression.

Original languageEnglish
Pages (from-to)284-289
Number of pages6
JournalJournal of Cystic Fibrosis
Volume12
Issue number3
Early online date04 Sept 2012
DOIs
Publication statusPublished - May 2013
Externally publishedYes

Bibliographical note

Funding Information:
Doug Forrester is funded by Wellcome Trust Fellowship WT088614MA .

Keywords

  • Body mass index
  • Cystic fibrosis
  • Lung function
  • Muscle

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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