Abstract
Background: Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung function in CF.
Methods: Cross-sectional study design using UK CF registry data from 2096 clinically stable adults.
Results: Serum creatinine and BMI were positively and independently associated with FEV1 and FVC. One standard deviation increment in serum creatinine was associated with an FEV1 increase of 171ml (95% confidence intervals CI: +116 to +227ml) in males and 90ml (95% CI: +46 to +133ml) in females. Compared to the reference group of 20-24.9kg/m2, those with a BMI<20kg/m2 had lower FEV1 with values of -642ml (95%CI: -784 to -500ml) for males and -468ml (95%CI: -564 to -372ml) for females.
Conclusions: Prospective studies and controlled trials are required to ascertain if these associations have therapeutic potential in modifying disease progression.
| Original language | English |
|---|---|
| Pages (from-to) | 284-289 |
| Number of pages | 6 |
| Journal | Journal of Cystic Fibrosis |
| Volume | 12 |
| Issue number | 3 |
| Early online date | 04 Sept 2012 |
| DOIs | |
| Publication status | Published - May 2013 |
| Externally published | Yes |
Bibliographical note
Funding Information:Doug Forrester is funded by Wellcome Trust Fellowship WT088614MA .
Keywords
- Body mass index
- Cystic fibrosis
- Lung function
- Muscle
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pulmonary and Respiratory Medicine
Access to Document
- Measures of body habitus are associated with lung function in adults with cystic fibrosis: A population-based study
© 2012 European Cystic Fibrosis Society. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.