Mechanical properties of α-tricalcium phosphate-based bone cements incorporating regenerative biomaterials for filling bone defects exposed to low mechanical loads

Reed Harrison, Zachary K. Criss, Lacie Feller, Shan P. Modi, John G. Hardy, Christine E. Schmidt, Laura J. Suggs, Matthew B. Murphy

Research output: Contribution to journalArticle

7 Citations (Scopus)
507 Downloads (Pure)

Abstract

Calcium phosphate-based cements with enhanced regenerative potential are promising biomaterials for the healing of bone defects. With a view to the use of such cements for low load bearing applications such as sinus augmentation or filling extraction sites, we have prepared α-tricalcium phosphate (α-TCP)-based bone cements including materials that we would expect to improve their regenerative potential, and describe the mechanical properities of the resulting formulations herein. Formulations incorporated α-TCP, hydroxyapatite, biopolymer-thickened wetting agents, sutures, and platelet poor plasma. The mechanical properties of the composites were composition dependent, and optimized formulations had clinically relevant mechanical properties. Such calcium phosphate-based cements have potential as replacements for cements such as those based on polymethylmethacrylate (PMMA).
Original languageEnglish
Pages (from-to)149-157
JournalJournal of Biomedical Materials Research - Part B: Applied Biomaterials
Volume104
Issue number1
Early online date10 Feb 2015
DOIs
Publication statusPublished - Jan 2016
Externally publishedYes

Keywords

  • Biodegradation
  • BIOMATERIALS
  • COMPOSITE
  • Minerals

ASJC Scopus subject areas

  • Biomaterials
  • Ceramics and Composites

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