Calcium phosphate-based cements with enhanced regenerative potential are promising biomaterials for the healing of bone defects. With a view to the use of such cements for low load bearing applications such as sinus augmentation or filling extraction sites, we have prepared α-tricalcium phosphate (α-TCP)-based bone cements including materials that we would expect to improve their regenerative potential, and describe the mechanical properities of the resulting formulations herein. Formulations incorporated α-TCP, hydroxyapatite, biopolymer-thickened wetting agents, sutures, and platelet poor plasma. The mechanical properties of the composites were composition dependent, and optimized formulations had clinically relevant mechanical properties. Such calcium phosphate-based cements have potential as replacements for cements such as those based on polymethylmethacrylate (PMMA).
|Journal||Journal of Biomedical Materials Research - Part B: Applied Biomaterials|
|Early online date||10 Feb 2015|
|Publication status||Published - Jan 2016|
ASJC Scopus subject areas
- Ceramics and Composites
Harrison, R., Criss, Z. K., Feller, L., Modi, S. P., Hardy, J. G., Schmidt, C. E., Suggs, L. J., & Murphy, M. B. (2016). Mechanical properties of α-tricalcium phosphate-based bone cements incorporating regenerative biomaterials for filling bone defects exposed to low mechanical loads. Journal of Biomedical Materials Research - Part B: Applied Biomaterials, 104(1), 149-157. https://doi.org/10.1002/jbm.b.33362