Mechanistic Modelling of Radiation Responses

Research output: Contribution to journalReview article

2 Citations (Scopus)
95 Downloads (Pure)

Abstract

Radiobiological modelling has been a key part of radiation biology and therapy for many decades, and many aspects of clinical practice are guided by tools such as the linear-quadratic model. However, most of the models in regular clinical use are abstract and empirical, and do not provide significant scope for mechanistic interpretation or making predictions in novel cell lines or therapies. In this review, we will discuss the key areas of ongoing mechanistic research in radiation biology, including physical, chemical, and biological steps, and review a range of mechanistic modelling approaches which are being applied in each area, highlighting the possible opportunities and challenges presented by these techniques.

Original languageEnglish
Article number205
Number of pages23
JournalCancers
Volume11
Issue number2
DOIs
Publication statusPublished - 10 Feb 2019

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Radiobiology
Radiation
Cell- and Tissue-Based Therapy
Linear Models
Radiotherapy
Cell Line
Research

Cite this

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title = "Mechanistic Modelling of Radiation Responses",
abstract = "Radiobiological modelling has been a key part of radiation biology and therapy for many decades, and many aspects of clinical practice are guided by tools such as the linear-quadratic model. However, most of the models in regular clinical use are abstract and empirical, and do not provide significant scope for mechanistic interpretation or making predictions in novel cell lines or therapies. In this review, we will discuss the key areas of ongoing mechanistic research in radiation biology, including physical, chemical, and biological steps, and review a range of mechanistic modelling approaches which are being applied in each area, highlighting the possible opportunities and challenges presented by these techniques.",
author = "McMahon, {Stephen J} and Prise, {Kevin M}",
year = "2019",
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doi = "10.3390/cancers11020205",
language = "English",
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journal = "Cancers",
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publisher = "MDPI AG",
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Mechanistic Modelling of Radiation Responses. / McMahon, Stephen J; Prise, Kevin M.

In: Cancers, Vol. 11, No. 2, 205, 10.02.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Mechanistic Modelling of Radiation Responses

AU - McMahon, Stephen J

AU - Prise, Kevin M

PY - 2019/2/10

Y1 - 2019/2/10

N2 - Radiobiological modelling has been a key part of radiation biology and therapy for many decades, and many aspects of clinical practice are guided by tools such as the linear-quadratic model. However, most of the models in regular clinical use are abstract and empirical, and do not provide significant scope for mechanistic interpretation or making predictions in novel cell lines or therapies. In this review, we will discuss the key areas of ongoing mechanistic research in radiation biology, including physical, chemical, and biological steps, and review a range of mechanistic modelling approaches which are being applied in each area, highlighting the possible opportunities and challenges presented by these techniques.

AB - Radiobiological modelling has been a key part of radiation biology and therapy for many decades, and many aspects of clinical practice are guided by tools such as the linear-quadratic model. However, most of the models in regular clinical use are abstract and empirical, and do not provide significant scope for mechanistic interpretation or making predictions in novel cell lines or therapies. In this review, we will discuss the key areas of ongoing mechanistic research in radiation biology, including physical, chemical, and biological steps, and review a range of mechanistic modelling approaches which are being applied in each area, highlighting the possible opportunities and challenges presented by these techniques.

U2 - 10.3390/cancers11020205

DO - 10.3390/cancers11020205

M3 - Review article

C2 - 30744204

VL - 11

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 2

M1 - 205

ER -