Mechanistic Modelling of Radiation Responses

Research output: Contribution to journalReview article

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185 Downloads (Pure)

Abstract

Radiobiological modelling has been a key part of radiation biology and therapy for many decades, and many aspects of clinical practice are guided by tools such as the linear-quadratic model. However, most of the models in regular clinical use are abstract and empirical, and do not provide significant scope for mechanistic interpretation or making predictions in novel cell lines or therapies. In this review, we will discuss the key areas of ongoing mechanistic research in radiation biology, including physical, chemical, and biological steps, and review a range of mechanistic modelling approaches which are being applied in each area, highlighting the possible opportunities and challenges presented by these techniques.

Original languageEnglish
Article number205
Number of pages23
JournalCancers
Volume11
Issue number2
DOIs
Publication statusPublished - 10 Feb 2019

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