Mediated electron transfer in glucose oxidising enzyme electrodes for application to biofuel cells: Recent progress and perspectives

Paul Kavanagh*, Dónal Leech

*Corresponding author for this work

Research output: Contribution to journalReview article

76 Citations (Scopus)

Abstract

Glucose oxidising enzyme electrodes have long been studied for their application to biosensors and, more recently, anodes in biofuel cells. At a fundamental level, insight into enzyme electron transfer and oxidation current generation at enzyme electrodes can be gained by systematic studies on integration of surfaces, biocatalysts, and artificial substrates (mediators). In this perspective, we present an overview of methods to aid the development of glucose oxidising enzyme electrodes based on mediated electron transfer for application to continuous-use anodes in a biofuel cell. Focus is placed on the rational design of mediators, based on osmium redox complexes, and screening of the activity of such complexes as mediators for glucose oxidising enzymes. An overview of the performance of enzyme electrodes, focused predominantly on crosslinked films of redox polymers and glucose oxidase, for glucose oxidation, is presented and approaches to improve both current output and stability of such enzyme electrodes are discussed.

Original languageEnglish
Pages (from-to)4859-4869
Number of pages11
Journal Physical Chemistry Chemical Physics
Volume15
Issue number14
DOIs
Publication statusPublished - 14 Apr 2013

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Biological fuel cells
Enzyme electrodes
glucose
enzymes
electron transfer
Glucose
electrodes
Electrons
cells
Anodes
Enzymes
Osmium
Oxidation
Glucose Oxidase
anodes
Biosensors
oxidation
Screening
osmium
oxidase

Cite this

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abstract = "Glucose oxidising enzyme electrodes have long been studied for their application to biosensors and, more recently, anodes in biofuel cells. At a fundamental level, insight into enzyme electron transfer and oxidation current generation at enzyme electrodes can be gained by systematic studies on integration of surfaces, biocatalysts, and artificial substrates (mediators). In this perspective, we present an overview of methods to aid the development of glucose oxidising enzyme electrodes based on mediated electron transfer for application to continuous-use anodes in a biofuel cell. Focus is placed on the rational design of mediators, based on osmium redox complexes, and screening of the activity of such complexes as mediators for glucose oxidising enzymes. An overview of the performance of enzyme electrodes, focused predominantly on crosslinked films of redox polymers and glucose oxidase, for glucose oxidation, is presented and approaches to improve both current output and stability of such enzyme electrodes are discussed.",
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Mediated electron transfer in glucose oxidising enzyme electrodes for application to biofuel cells : Recent progress and perspectives. / Kavanagh, Paul; Leech, Dónal.

In: Physical Chemistry Chemical Physics , Vol. 15, No. 14, 14.04.2013, p. 4859-4869.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Mediated electron transfer in glucose oxidising enzyme electrodes for application to biofuel cells

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AU - Kavanagh, Paul

AU - Leech, Dónal

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