Medical characteristics of patients with macular telangiectasia type 2 (MacTel Type 2) MacTel project report no. 3

Traci E Clemons, Mark C Gillies, Emily Y Chew, Alan C Bird, Tunde Peto, Jie Jin Wang, Paul Mitchell, Wishal D Ramdas, Johannes R Vingerling, Macular Telangiectasia Project Research Group

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


PURPOSE: To determine whether the prevalences of various systemic conditions in participants of the MacTel Project Natural History Observation (NHO) Study differ from the corresponding prevalences in the general population.

METHODS: This report compares the prevalence of systemic disease in participants of the NHO Study with age- and sex-matched controls from three population-based studies from the US, the Netherlands and Australia. Bootstrap simulations were used to evaluate the impact and reliability of the computed statistics.

RESULTS: We identified a number of systemic conditions that appear to be more prevalent in cases with macular telangiectasia (MacTel) Type 2 than in the general population that were matched for age and sex with the MacTel cases. Patients with MacTel Type 2 had significantly increased prevalence of diabetes mellitus, higher prevalence of obesity, hypertension and history of cardiovascular disease, compared to their same-aged peers in generally older communities.

CONCLUSION: Systemic disease associated with MacTel Type 2 may help to improve understanding of possible causes of MacTel Type 2. It is hoped that future studies will help to improve our understanding of the pathogenesis of the condition and lead to potential treatments for this ocular disease.

Original languageEnglish
Pages (from-to)109-13
Number of pages5
JournalOphthalmic Epidemiology
Issue number2
Early online date19 Mar 2013
Publication statusPublished - Apr 2013
Externally publishedYes


  • Cardiovascular Diseases
  • Cohort Studies
  • Diabetes Mellitus
  • Female
  • Fluorescein Angiography
  • Humans
  • Hypertension
  • Male
  • Middle Aged
  • Nutrition Surveys
  • Obesity
  • Prevalence
  • Retinal Telangiectasis
  • Tomography, Optical Coherence
  • United States
  • Visual Acuity
  • Comparative Study
  • Journal Article
  • Multicenter Study

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