Medical characteristics of patients with macular telangiectasia type 2 (MacTel Type 2) MacTel project report no. 3

Traci E Clemons; Mark C Gillies; Emily Y Chew; Alan C Bird; Tunde Peto; Jie Jin Wang; Paul Mitchell; Wishal D Ramdas; Johannes R Vingerling; Macular Telangiectasia Project Research Group

doi:10.3109/09286586.2013.766757

Medical characteristics of patients with macular telangiectasia type 2 (MacTel Type 2) MacTel project report no. 3

Traci E Clemons, Mark C Gillies, Emily Y Chew, Alan C Bird, Tunde Peto, Jie Jin Wang, Paul Mitchell, Wishal D Ramdas, Johannes R Vingerling, Macular Telangiectasia Project Research Group

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

PURPOSE: To determine whether the prevalences of various systemic conditions in participants of the MacTel Project Natural History Observation (NHO) Study differ from the corresponding prevalences in the general population.

METHODS: This report compares the prevalence of systemic disease in participants of the NHO Study with age- and sex-matched controls from three population-based studies from the US, the Netherlands and Australia. Bootstrap simulations were used to evaluate the impact and reliability of the computed statistics.

RESULTS: We identified a number of systemic conditions that appear to be more prevalent in cases with macular telangiectasia (MacTel) Type 2 than in the general population that were matched for age and sex with the MacTel cases. Patients with MacTel Type 2 had significantly increased prevalence of diabetes mellitus, higher prevalence of obesity, hypertension and history of cardiovascular disease, compared to their same-aged peers in generally older communities.

CONCLUSION: Systemic disease associated with MacTel Type 2 may help to improve understanding of possible causes of MacTel Type 2. It is hoped that future studies will help to improve our understanding of the pathogenesis of the condition and lead to potential treatments for this ocular disease.

Original language	English
Pages (from-to)	109-13
Number of pages	5
Journal	Ophthalmic Epidemiology
Volume	20
Issue number	2
Early online date	19 Mar 2013
DOIs	https://doi.org/10.3109/09286586.2013.766757
Publication status	Published - Apr 2013
Externally published	Yes

Keywords

Cardiovascular Diseases
Cohort Studies
Diabetes Mellitus
Female
Fluorescein Angiography
Humans
Hypertension
Male
Middle Aged
Nutrition Surveys
Obesity
Prevalence
Retinal Telangiectasis
Tomography, Optical Coherence
United States
Visual Acuity
Comparative Study
Journal Article
Multicenter Study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Clemons, T. E., Gillies, M. C., Chew, E. Y., Bird, A. C., Peto, T., Wang, J. J., Mitchell, P., Ramdas, W. D., Vingerling, J. R., & Macular Telangiectasia Project Research Group (2013). Medical characteristics of patients with macular telangiectasia type 2 (MacTel Type 2) MacTel project report no. 3. Ophthalmic Epidemiology, 20(2), 109-13. https://doi.org/10.3109/09286586.2013.766757

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abstract = "PURPOSE: To determine whether the prevalences of various systemic conditions in participants of the MacTel Project Natural History Observation (NHO) Study differ from the corresponding prevalences in the general population.METHODS: This report compares the prevalence of systemic disease in participants of the NHO Study with age- and sex-matched controls from three population-based studies from the US, the Netherlands and Australia. Bootstrap simulations were used to evaluate the impact and reliability of the computed statistics.RESULTS: We identified a number of systemic conditions that appear to be more prevalent in cases with macular telangiectasia (MacTel) Type 2 than in the general population that were matched for age and sex with the MacTel cases. Patients with MacTel Type 2 had significantly increased prevalence of diabetes mellitus, higher prevalence of obesity, hypertension and history of cardiovascular disease, compared to their same-aged peers in generally older communities.CONCLUSION: Systemic disease associated with MacTel Type 2 may help to improve understanding of possible causes of MacTel Type 2. It is hoped that future studies will help to improve our understanding of the pathogenesis of the condition and lead to potential treatments for this ocular disease.",

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author = "Clemons, {Traci E} and Gillies, {Mark C} and Chew, {Emily Y} and Bird, {Alan C} and Tunde Peto and Wang, {Jie Jin} and Paul Mitchell and Ramdas, {Wishal D} and Vingerling, {Johannes R} and {Macular Telangiectasia Project Research Group}",

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doi = "10.3109/09286586.2013.766757",

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pages = "109--13",

journal = "Ophthalmic Epidemiology",

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Clemons, TE, Gillies, MC, Chew, EY, Bird, AC, Peto, T, Wang, JJ, Mitchell, P, Ramdas, WD, Vingerling, JR & Macular Telangiectasia Project Research Group 2013, 'Medical characteristics of patients with macular telangiectasia type 2 (MacTel Type 2) MacTel project report no. 3', Ophthalmic Epidemiology, vol. 20, no. 2, pp. 109-13. https://doi.org/10.3109/09286586.2013.766757

TY - JOUR

T1 - Medical characteristics of patients with macular telangiectasia type 2 (MacTel Type 2) MacTel project report no. 3

AU - Clemons, Traci E

AU - Gillies, Mark C

AU - Chew, Emily Y

AU - Bird, Alan C

AU - Peto, Tunde

AU - Wang, Jie Jin

AU - Mitchell, Paul

AU - Ramdas, Wishal D

AU - Vingerling, Johannes R

AU - Macular Telangiectasia Project Research Group

PY - 2013/4

Y1 - 2013/4

N2 - PURPOSE: To determine whether the prevalences of various systemic conditions in participants of the MacTel Project Natural History Observation (NHO) Study differ from the corresponding prevalences in the general population.METHODS: This report compares the prevalence of systemic disease in participants of the NHO Study with age- and sex-matched controls from three population-based studies from the US, the Netherlands and Australia. Bootstrap simulations were used to evaluate the impact and reliability of the computed statistics.RESULTS: We identified a number of systemic conditions that appear to be more prevalent in cases with macular telangiectasia (MacTel) Type 2 than in the general population that were matched for age and sex with the MacTel cases. Patients with MacTel Type 2 had significantly increased prevalence of diabetes mellitus, higher prevalence of obesity, hypertension and history of cardiovascular disease, compared to their same-aged peers in generally older communities.CONCLUSION: Systemic disease associated with MacTel Type 2 may help to improve understanding of possible causes of MacTel Type 2. It is hoped that future studies will help to improve our understanding of the pathogenesis of the condition and lead to potential treatments for this ocular disease.

AB - PURPOSE: To determine whether the prevalences of various systemic conditions in participants of the MacTel Project Natural History Observation (NHO) Study differ from the corresponding prevalences in the general population.METHODS: This report compares the prevalence of systemic disease in participants of the NHO Study with age- and sex-matched controls from three population-based studies from the US, the Netherlands and Australia. Bootstrap simulations were used to evaluate the impact and reliability of the computed statistics.RESULTS: We identified a number of systemic conditions that appear to be more prevalent in cases with macular telangiectasia (MacTel) Type 2 than in the general population that were matched for age and sex with the MacTel cases. Patients with MacTel Type 2 had significantly increased prevalence of diabetes mellitus, higher prevalence of obesity, hypertension and history of cardiovascular disease, compared to their same-aged peers in generally older communities.CONCLUSION: Systemic disease associated with MacTel Type 2 may help to improve understanding of possible causes of MacTel Type 2. It is hoped that future studies will help to improve our understanding of the pathogenesis of the condition and lead to potential treatments for this ocular disease.

KW - Cardiovascular Diseases

KW - Cohort Studies

KW - Diabetes Mellitus

KW - Female

KW - Fluorescein Angiography

KW - Humans

KW - Hypertension

KW - Male

KW - Middle Aged

KW - Nutrition Surveys

KW - Obesity

KW - Prevalence

KW - Retinal Telangiectasis

KW - Tomography, Optical Coherence

KW - United States

KW - Visual Acuity

KW - Comparative Study

KW - Journal Article

KW - Multicenter Study

U2 - 10.3109/09286586.2013.766757

DO - 10.3109/09286586.2013.766757

M3 - Article

C2 - 23510315

SN - 0928-6586

VL - 20

SP - 109

EP - 113

JO - Ophthalmic Epidemiology

JF - Ophthalmic Epidemiology

IS - 2

ER -

Medical characteristics of patients with macular telangiectasia type 2 (MacTel Type 2) MacTel project report no. 3

Abstract

Keywords

UN SDGs

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