Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort

E. Molina-Montes, M. J. Sanchez, G. Buckland, H. B. Bueno-de-Mesquita, E. Weiderpass, P. Amiano, P. A. Wark, T. Kuhn, V. Katzke, J. M. Huerta, E. Ardanaz, J. R. Quiros, A. Affret, M. His, M. C. Boutron-Ruault, P. H. Peeters, W. Ye, M. Sund, H. Boeing, K. IqbalB. Ohlsson, E. Sonestedt, A. Tjonneland, K. E. Petersen, R. C. Travis, G. Skeie, C. Agnoli, S. Panico, D. Palli, R. Tumino, C. Sacerdote, H. Freisling, I. Huybrechts, K. Overvad, A. Trichopoulou, C. Bamia, E. Vasilopoulou, N. Wareham, K. T. Khaw, A. J. Cross, H. A. Ward, E. Riboli, E. J. Duell

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Abstract

Background: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been
accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD
and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Methods: Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly
diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the
alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age,
sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were
used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs).
Results: Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence ¼ 0.99; 95%
CI: 0.77–1.26, and HR per increments of two units in adherence to arMED ¼ 1.00; 95% CI: 0.94–1.06). There was no convincing
evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of
significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other
definitions of the MD pattern.
Conclusions: A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.
Original languageEnglish
Pages (from-to)811-820
Number of pages10
JournalBritish Journal of Cancer
Volume116
Issue number6
DOIs
Publication statusPublished - 07 Feb 2017

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    Molina-Montes, E., Sanchez, M. J., Buckland, G., Bueno-de-Mesquita, H. B., Weiderpass, E., Amiano, P., Wark, P. A., Kuhn, T., Katzke, V., Huerta, J. M., Ardanaz, E., Quiros, J. R., Affret, A., His, M., Boutron-Ruault, M. C., Peeters, P. H., Ye, W., Sund, M., Boeing, H., ... Duell, E. J. (2017). Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort. British Journal of Cancer, 116(6), 811-820. https://doi.org/10.1038/bjc.2017.14