Mesenchymal stem cells in immunoregulation

Marilyn Armstrong, X. Chen, Gang Li

Research output: Contribution to journalArticlepeer-review

166 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) reside within the bone marrow cavity and serve as a reservoir for the continuous renovation of various mesenchymal tissues. Recent efforts suggest that MSCs modulate the immune reactions in vitro and escape the immune surveillance in vivo. We provide herein a discussion of the issues including the current research progress on the in vitro interactions of MSCs with multiple subsets of immune cells (dendritic cells, T cells, B cells and natural killer cells), in vivo transplantation outcomes, the possible underlying mechanisms, future research directions as well as potential clinical implications.
Original languageEnglish
Pages (from-to)413-421
Number of pages9
JournalImmunology and Cell Biology
Volume84
Issue number5
Publication statusPublished - May 2006

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Immunology

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