Metabolic shifts in immunity and inflammation

Douglas J. Kominsky, Eric L. Campbell, Sean P. Colgan

Research output: Contribution to journalShort surveypeer-review

213 Citations (Scopus)

Abstract

Sites of ongoing inflammation and triggered immune responses are characterized by significant changes in metabolic activity. Recent studies have indicated that such shifts in tissue metabolism result from a combination of profound recruitment of inflammatory cells (neutrophils and monocytes) and high proliferation rates among lymphocyte populations. The resultant shifts in energy supply and demand can result in metabolic acidosis and diminished delivery and/or availability of oxygen, leading to hypoxia extensive enough to trigger transcriptional and translation changes in tissue phenotype. Such phenotypic shifts can imprint fundamental changes to tissue metabolism. In this study, we review recent work addressing metabolic changes and metabolic control of inflammation and immunity.

Original languageEnglish
Pages (from-to)4062-4068
Number of pages7
JournalJournal of Immunology
Volume184
Issue number8
DOIs
Publication statusPublished - 15 Apr 2010
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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