Metabolomics reveal circadian control of cellular metabolism

Ratnasekhar Ch*, Olivier Chevallier, Christopher T. Elliott

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Circadian rhythms are a fundamental feature of all organisms from cyanobacteria to humans and govern all aspect of physiology and behaviours. These rhythms exist in individual cells to the entire organism and are driven by cell-autonomous molecular circadian clocks. A significant fraction of cellular metabolome varies according to the time of the day. Disruption of circadian rhythms leads to aberrations in cellular metabolism associated with metabolic disorders such as obesity, type 2 diabetes and cardiovascular problems. Recent advances in analytical technology and the application of metabolomics studies have identified the metabolite biomarkers and revealed the role of metabolism in circadian rhythms and the molecular mechanisms through which the circadian system regulates metabolism. The main aim of this review is to present the most recent advances of metabolomics studies to reveal baseline circadian metabolism studies in human, mice, Drosophila melanogaster and cyanobacteria.

Original languageEnglish
Article number115986
JournalTrAC - Trends in Analytical Chemistry
Volume130
DOIs
Publication statusEarly online date - 28 Jul 2020

Keywords

  • Biological clock
  • Circadian rhythms
  • Drosophila and cyanobacteria
  • Human
  • Mass spectrometry
  • Metabolism
  • Metabolomics
  • Mice

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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