Metabolomics reveals novel biomarkers of illegal 5-nitromimidazole treatment in pigs. Further evidence of drug toxicity uncovered

M. Arias , O. P. Chevallier, S. F. Graham, A. Gasull-Gimenez, T. Fodey, K. M. Cooper, S.R.H. Crooks, M. Danaher, Christopher T. Elliott

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The aim of the study was to investigate the potential of a metabolomics platform to distinguish between pigs treated with ronidazole, dimetridazole and metronidazole and non-medicated animals (controls), at two withdrawal periods (day 0 and 5). Livers from each animal were biochemically profiled using UHPLC–QTof-MS in ESI+ mode of acquisition. Several Orthogonal Partial Least Squares-Discriminant Analysis models were generated from the acquired mass spectrometry data. The models classified the two groups control and treated animals. A total of 42 ions of interest explained the variation in ESI+. It was possible to find the identity of 3 of the ions and to positively classify 4 of the ionic features, which can be used as potential biomarkers of illicit 5-nitroimidazole abuse. Further evidence of the toxic mechanisms of 5-nitroimidazole drugs has been revealed, which may be of substantial importance as metronidazole is widely used in human medicine.
Original languageEnglish
Pages (from-to)876-884
Number of pages9
JournalFood Chemistry
Volume199
Early online date18 Dec 2015
DOIs
Publication statusPublished - 15 May 2016

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