Metal organic frameworks as NO delivery materials for biological applications

Nathan J. Hinks, Alistair C. McKinlay, Bo Xiao, Paul S. Wheatley, Russell E. Morris

Research output: Contribution to journalArticlepeer-review

165 Citations (Scopus)

Abstract

Metal organic frameworks (MOFs) are highly porous materials that can store significant amounts of gas, including nitric oxide. The chemical composition and toxicology of many (but not all) of these materials makes them potentially suitable for medical applications. In this paper, we will describe how triggered release methods can be used to deliver biologically relevant amounts of NO and then show how Ni, Co and Cu-containing MOFs are biologically active materials with potential applications in several different areas (anti-thrombosis, dermatology and wound healing, anti-bacterial, vasodilation etc.). We will also discuss the pros and cons of MOFs, including their chemical and biological stability and the toxicology of MOFs in general. (C) 2009 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)330-334
Number of pages5
JournalMICROPOROUS AND MESOPOROUS MATERIALS
Volume129
Issue number3
DOIs
Publication statusPublished - 15 Apr 2010

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